CLOCK and CEP135

		CLOCK	CEP135
Description		clock circadian regulator	centrosomal protein 135
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Chromatoid Body CLOCK-BMAL Transcription Complex	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Damage Checkpoint Signaling Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation DNA Damage Response Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Centriole Replication Centriole-centriole Cohesion Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression HATs acetylate histones Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
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Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: ARNT BHLHE41 BMAL1 BMAL2 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	2 interacting genes: PIBF1 SMAD9
Entrez ID		9575	9662
HPRD ID		03508	11097
Ensembl ID		ENSG00000134852	ENSG00000174799
Uniprot IDs		O15516 Q3ZCT4 Q53EU0	Q66GS9
PDB IDs		4H10 6QPJ	5FCN 5NG4
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Photoperiodism Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Chromatin Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nuclear Receptor Activity Gluconeogenesis Hexose Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Carbohydrate Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Negative Regulation Of Circadian Rhythm Carbohydrate Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Metabolic Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	DNA-binding Transcription Factor Activity Transcription Regulator Complex Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Insulin Secretion Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Amniotic Stem Cell Differentiation Regulation Of Peptide Hormone Secretion Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cortisol Biosynthetic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Mesenchymal Stem Cell Differentiation Protein Modification Process CLOCK-BMAL Transcription Complex Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Negative Regulation Of Prostaglandin Biosynthetic Process Activation Of Janus Kinase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Adult Feeding Behavior Righting Reflex Behavioral Response To Ethanol Positive Regulation Of Metabolic Process Regulation Of Hormone Secretion Cellular Response To Electrical Stimulus Regulation Of Protein Secretion Regulation Of Glucocorticoid Metabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cardiac Muscle Cell Myoblast Differentiation Regulation Of Prostaglandin Biosynthetic Process Host-mediated Suppression Of Viral Transcription Cardioblast Differentiation Chromatoid Body
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