RORB and MID2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RORB	MID2
Description		RAR related orphan receptor B	midline 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Cytoskeleton Microtubule Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cellular Response To Retinoic Acid	Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Viral Transcription Protein Localization To Microtubule Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Intracellular Signal Transduction
Pathways		Nuclear Receptor transcription pathway Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Melatonin
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Hyperopia ( 33830181) Immature fraction of reticulocytes ( 32888494) Low myopia vs hyperopia ( 33830181) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 MTCL2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587	237 interacting genes: ADAMTSL4 AEN ALDH3B1 ANKS1A AP1M1 AQP1 ARHGEF5 ATOSA ATOSB ATRIP AXIN1 BAHD1 BCL6B BLK BLZF1 BRCA1 BRMS1L BYSL C1orf35 CALCOCO2 CARD9 CARHSP1 CBX8 CCDC120 CCDC185 CCDC187 CCDC33 CCDC42 CCHCR1 CDK18 CEP57L1 CFP CHD2 CNNM3 COX5B CPSF4 CRACR2A CREBRF CTSZ DCX DGCR6 DGCR6L DMRT3 DRC4 DYDC1 EFHC2 EGFL7 EIF1AD ELOA ENKD1 EPN2 ETNK2 FAM107A FAM161A FAM161B FAM50B FAM90A1 FARS2 FASTKD5 FBF1 FBXL18 FBXW5 FOXD4L3 FRMD6 FSD2 GAS2L2 GCC1 GEM GFI1B GMCL1 GOLGA2 GOLGA7 GORASP2 GPANK1 GPKOW GSC2 HAPLN2 HCK HDAC4 HDX HNRNPLL HOXB2 HOXB5 HOXB9 IGBP1 IGFN1 IHO1 IKZF3 IL16 INO80B IQCN ISCU ITGB4 JOSD1 KANK2 KIF1A KIF9 KIFC3 KRT27 KRT31 KRT40 KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS8 LMNB2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LRRC45 LZTS1 LZTS2 MAGEA6 MAGOHB MEOX1 MEOX2 METTL17 MFAP1 MID1 MID1IP1 MOS MVP NCOA4 NR1D2 NSMF NXF1 OTUB2 PICK1 PKN1 POLDIP3 PPP1R18 PRDM16 PRPF3 PRPF31 PSMA1 PTCD2 PTPDC1 QARS1 RABGEF1 RANBP3L RCOR3 REL RLN1 RNF6 RORB RPH3AL RPP25L RUNX1T1 RXRB SCNM1 SDCBP SEPTIN1 SHFL SLC25A48 SLC25A6 SNAI1 SNAP47 SPAG5 SPATA24 SPG21 SPRY2 STX11 SYNGAP1 TASOR2 TBC1D22B TCAF1 TCEA2 TCEANC TEKT1 THAP7 TMEM14B TOP3B TRIM27 TRIM29 TRIM32 TRIM41 TRIM42 TRIM54 TRIM69 TRPV6 TSGA10 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K UBE2U UBTD1 UNC45A USP2 USP25 USP54 UTP23 UTP25 WT1-AS ZBTB16 ZBTB24 ZBTB42 ZC2HC1C ZFYVE21 ZGPAT ZIM2 ZNF124 ZNF165 ZNF177 ZNF24 ZNF250 ZNF266 ZNF408 ZNF410 ZNF417 ZNF438 ZNF440 ZNF451 ZNF497 ZNF552 ZNF559-ZNF177 ZNF564 ZNF587 ZNF648 ZNF669 ZNF688 ZNF696 ZNF764 ZNF774 ZNF784 ZNF785 ZNF792 ZRANB1 ZSCAN12
Entrez ID		6096	11043
HPRD ID		09062	02191
Ensembl ID		ENSG00000198963	ENSG00000080561
Uniprot IDs		A0A1L4FMK7 Q58EY0 Q92753	Q6GX22 Q9UJV3
PDB IDs			2DJA 2DMK 7QRZ
Enriched GO Terms of Interacting Partners?		Nuclear Retinoid X Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Regulation Of Metabolic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process ITP Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Proteasome-activating Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process UTP Biosynthetic Process Nuclear Receptor Binding Regulation Of Macromolecule Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signaling Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process CTP Biosynthetic Process Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Macromolecule Biosynthetic Process CTP Metabolic Process Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Circadian Regulation Of Gene Expression Protein Localization To Microtubule Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteasome Accessory Complex Negative Regulation Of Transcription By RNA Polymerase II Transcription Factor Binding Positive Regulation Of Circadian Rhythm GTP Metabolic Process Transcription Corepressor Activity Pyrimidine Ribonucleotide Biosynthetic Process Macromolecule Catabolic Process	Protein Binding Zinc Ion Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Ubiquitin Conjugating Enzyme Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Microtubule Binding Post-translational Protein Modification Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding Protein Polyubiquitination Cytoskeleton Negative Regulation Of RNA Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Protein Ubiquitination Regulation Of Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Identical Protein Binding
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