RORB and NRIP2

Number of citations of the paper that reports this interaction (PubMedID 10860982)
32

Data Source:
HPRD (in vitro, in vivo)

		RORB	NRIP2
Description		RAR related orphan receptor B	nuclear receptor interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Notch Signaling Pathway
Pathways		Nuclear Receptor transcription pathway Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Melatonin
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Hyperopia ( 33830181) Immature fraction of reticulocytes ( 32888494) Low myopia vs hyperopia ( 33830181) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 MTCL2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587	8 interacting genes: AKT1 BANP CCNG2 ELF5 HDAC7 RARA RORB ZNF76
Entrez ID		6096	83714
HPRD ID		09062	14839
Ensembl ID		ENSG00000198963	ENSG00000053702
Uniprot IDs		A0A1L4FMK7 Q58EY0 Q92753	Q9BQI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Retinoid X Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Regulation Of Metabolic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process ITP Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Proteasome-activating Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process UTP Biosynthetic Process Nuclear Receptor Binding Regulation Of Macromolecule Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signaling Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process CTP Biosynthetic Process Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Macromolecule Biosynthetic Process CTP Metabolic Process Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Circadian Regulation Of Gene Expression Protein Localization To Microtubule Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteasome Accessory Complex Negative Regulation Of Transcription By RNA Polymerase II Transcription Factor Binding Positive Regulation Of Circadian Rhythm GTP Metabolic Process Transcription Corepressor Activity Pyrimidine Ribonucleotide Biosynthetic Process Macromolecule Catabolic Process	Mammary Gland Epithelial Cell Differentiation Sequence-specific DNA Binding 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Regulation Of Myelination Negative Regulation Of Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of RNA Biosynthetic Process Striated Muscle Cell Differentiation Regulation Of Cell Differentiation Nucleus Regulation Of TRNA Methylation Positive Regulation Of DNA-templated Transcription Sertoli Cell Fate Commitment Nuclear Receptor Activity Cellular Response To Retinoic Acid Negative Regulation Of Osteoblast Differentiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Lysosome DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Ectodermal Cell Fate Commitment DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Response To Lipid Response To Retinoic Acid Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of RNA Metabolic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Muscle Cell Differentiation Positive Regulation Of Endothelial Cell Migration Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity DNA Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Trachea Cartilage Development
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