FASTKD5 and MAVS

		FASTKD5	MAVS
Description		FAST kinase domains 5	mitochondrial antiviral signaling protein
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane
	Molecular Function	RNA Binding Protein Binding RRNA Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Mitochondrial RNA Processing MRNA Processing Regulation Of Mitochondrial MRNA Stability	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		FASTK family proteins regulate processing and stability of mitochondrial RNAs	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs
Diseases
GWAS		Household income ( 31844048) Household income (MTAG) ( 31844048) Night sleep phenotypes ( 27126917)	Platelet distribution width ( 32888494)
Interacting Genes		6 interacting genes: CCDC85B KCNH1 MID2 MTUS2 RNF10 TRIM27	32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25
Entrez ID		60493	57506
HPRD ID		07813	13847
Ensembl ID		ENSG00000215251	ENSG00000088888
Uniprot IDs		Q7L8L6	Q7Z434
PDB IDs			2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW
Enriched GO Terms of Interacting Partners?		Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Negative Regulation Of Viral Process Regulation Of Viral Transcription Regulation Of Viral Process	Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol
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