RNASE1 and TRIM7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNASE1	TRIM7
Description		ribonuclease A family member 1, pancreatic	tripartite motif containing 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Nucleus Cytoplasm Golgi Apparatus
	Molecular Function	Nucleic Acid Binding Nuclease Activity Endonuclease Activity Ribonuclease A Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Defense Response To Gram-positive Bacterium Defense Response To Virus	Protein Ubiquitination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Chaperone Mediated Autophagy Late endosomal microautophagy Developmental Lineage of Pancreatic Acinar Cells
Drugs		Aspartic acid Guanidine Adenosine 3',5'-diphosphate 3'-Phosphate-Adenosine-5'-Diphosphate Formic acid Cytidine 3'-monophosphate Adenosine-2'-5'-Diphosphate 2'-Monophosphoadenosine-5'-Diphosphate 2'-deoxycytidine-2'-deoxyadenosine-3',5'-monophosphate 3'-Uridinemonophosphate Arabinouridine 3'-phosphate Cysteine-S-acetamide 2'-fluoro-2'-deoxyuridine 3'-monophosphate Adenylate-3'-phosphate-[[2'-deoxy-uridine-5'-phosphate]-3'-phosphate] Deoxycytidylyl-3',5'-guanosine Uridylyl-2'-5'-phospho-adenosine 2'-Deoxyuridine 3'-Monophosphate Uridine-2',3'-vanadate Purine Riboside-5'-Monophosphate 2'-cytidylic acid 5-Aminouracil tert-butanol Citric acid N-Formylmethionine Uridylyl-2'-5'-phospho-guanosine 5'-deoxy-5'-piperidin-1-ylthymidine 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: RELA RNH1 TRIM7	30 interacting genes: AQP1 ATG7 BCAM CDK13 CFL2 CRYGC CTNNAL1 DES GTF2A2 GYG1 IRAK4 MAD2L2 NAA35 NABP1 OTUD6A RAB2A RIN1 RNASE1 RNF187 RSPH14 SIAH1 SRC TP53I13 TRMT10A UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N UBE2W
Entrez ID		6035	81786
HPRD ID		01591	11648
Ensembl ID		ENSG00000129538	ENSG00000146054
Uniprot IDs		P07998 W0UV93	Q9C029
PDB IDs		1DZA 1E21 1H8X 1Z7X 2E0J 2E0L 2E0M 2E0O 2K11 2Q4G 3F8G 4KXH	6UMA 6UMB 7OVX 7OW2 7W0Q 7W0S 7W0T 7X6Y 7X6Z 7X70 7Y3A 7Y3B 7Y3C 8A5L 8A5M 8A8X 8R5B 8R5C 8R5D 9HIN
Enriched GO Terms of Interacting Partners?		Regulation Of Vasculature Development NF-kappaB P50/p65 Complex Ankyrin Repeat Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Antiviral Innate Immune Response Regulation Of Schwann Cell Differentiation Postsynapse To Nucleus Signaling Pathway Defense Response To Virus Positive Regulation Of Schwann Cell Differentiation Cellular Response To Peptidoglycan Negative Regulation Of Catabolic Process NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Angiogenesis Response To Cobalamin Cellular Response To Nicotine TRNA Stabilization Ribonuclease Inhibitor Activity Angiogenin-PRI Complex Response To Virus Negative Regulation Of Translation In Response To Stress Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipoteichoic Acid Response To Peptidoglycan Phosphate Ion Binding Defense Response To Tumor Cell General Transcription Initiation Factor Binding Negative Regulation Of Protein Sumoylation Actinin Binding Cellular Response To Interleukin-6 Response To Hepatocyte Growth Factor Cellular Response To Angiotensin Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Amyloid-beta Formation Response To Interleukin-6 Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Response To Morphine RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Muramyl Dipeptide Response To UV-B Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Protein Sumoylation Regulation Of Translation In Response To Stress Innate Immune Response Response To Muscle Stretch Negative Regulation Of MiRNA Transcription Interleukin-1-mediated Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Proteolysis Regulation Of TORC1 Signaling Macromolecule Catabolic Process Protein Modification Process Cytosol Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of TOR Signaling Catabolic Process Protein Autoubiquitination Nucleus Ubiquitin Protein Ligase Activity Extracellular Exosome ATP Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Intracellular Signal Transduction Protein Binding Endolysosomal Toll-like Receptor Signaling Pathway Macromolecule Metabolic Process Ephrin Receptor Binding Regulation Of Protein Polyubiquitination Ficolin-1-rich Granule Lumen Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Supramolecular Fiber Organization Defense Response To Virus Response To Nutrient Levels Postreplication Repair
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