RNASE1 and RNH1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		RNASE1	RNH1
Description		ribonuclease A family member 1, pancreatic	ribonuclease/angiogenin inhibitor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Angiogenin-PRI Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Nuclease Activity Endonuclease Activity Ribonuclease A Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity	Protein Binding Ribonuclease Inhibitor Activity
	Biological Process	Defense Response To Gram-positive Bacterium Defense Response To Virus	Cytoplasmic Translation MRNA Catabolic Process Cell Migration Negative Regulation Of Translation In Response To Stress Regulation Of Arp2/3 Complex-mediated Actin Nucleation TRNA Stabilization Regulation Of Angiogenesis
Pathways		Chaperone Mediated Autophagy Late endosomal microautophagy Developmental Lineage of Pancreatic Acinar Cells
Drugs		Aspartic acid Guanidine Adenosine 3',5'-diphosphate 3'-Phosphate-Adenosine-5'-Diphosphate Formic acid Cytidine 3'-monophosphate Adenosine-2'-5'-Diphosphate 2'-Monophosphoadenosine-5'-Diphosphate 2'-deoxycytidine-2'-deoxyadenosine-3',5'-monophosphate 3'-Uridinemonophosphate Arabinouridine 3'-phosphate Cysteine-S-acetamide 2'-fluoro-2'-deoxyuridine 3'-monophosphate Adenylate-3'-phosphate-[[2'-deoxy-uridine-5'-phosphate]-3'-phosphate] Deoxycytidylyl-3',5'-guanosine Uridylyl-2'-5'-phospho-adenosine 2'-Deoxyuridine 3'-Monophosphate Uridine-2',3'-vanadate Purine Riboside-5'-Monophosphate 2'-cytidylic acid 5-Aminouracil tert-butanol Citric acid N-Formylmethionine Uridylyl-2'-5'-phospho-guanosine 5'-deoxy-5'-piperidin-1-ylthymidine 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)	Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		3 interacting genes: RELA RNH1 TRIM7	5 interacting genes: ANG CEBPA OGT RNASE1 SDCBP
Entrez ID		6035	6050
HPRD ID		01591	01412
Ensembl ID		ENSG00000129538	ENSG00000023191
Uniprot IDs		P07998 W0UV93	A0A140VJT8 P13489
PDB IDs		1DZA 1E21 1H8X 1Z7X 2E0J 2E0L 2E0M 2E0O 2K11 2Q4G 3F8G 4KXH	1A4Y 1Z7X 2BEX 2Q4G
Enriched GO Terms of Interacting Partners?		Regulation Of Vasculature Development NF-kappaB P50/p65 Complex Ankyrin Repeat Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Antiviral Innate Immune Response Regulation Of Schwann Cell Differentiation Postsynapse To Nucleus Signaling Pathway Defense Response To Virus Positive Regulation Of Schwann Cell Differentiation Cellular Response To Peptidoglycan Negative Regulation Of Catabolic Process NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Angiogenesis Response To Cobalamin Cellular Response To Nicotine TRNA Stabilization Ribonuclease Inhibitor Activity Angiogenin-PRI Complex Response To Virus Negative Regulation Of Translation In Response To Stress Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipoteichoic Acid Response To Peptidoglycan Phosphate Ion Binding Defense Response To Tumor Cell General Transcription Initiation Factor Binding Negative Regulation Of Protein Sumoylation Actinin Binding Cellular Response To Interleukin-6 Response To Hepatocyte Growth Factor Cellular Response To Angiotensin Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Amyloid-beta Formation Response To Interleukin-6 Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Response To Morphine RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Muramyl Dipeptide Response To UV-B Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Protein Sumoylation Regulation Of Translation In Response To Stress Innate Immune Response Response To Muscle Stretch Negative Regulation Of MiRNA Transcription Interleukin-1-mediated Signaling Pathway	Peptide Binding Hematopoietic Stem Cell Proliferation RNA Nuclease Activity Organelle Organization Negative Regulation Of RNA Metabolic Process Defense Response To Gram-positive Bacterium Endonuclease Activity Defense Response Regulation Of Phosphorus Metabolic Process Cell Communication Stem Cell Proliferation Response To Stress TRNA-specific Ribonuclease Activity Protein-containing Complex Organization Angiogenin-PRI Complex Nuclease Activity Macromolecule Biosynthetic Process Protein-containing Complex Assembly Animal Organ Development Cytoplasmic Translation Signaling Cellular Component Assembly Response To Hormone Cell Maturation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Nuclear Pore Cytoplasmic Filaments Ribonuclease A Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly
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