RNASE1

Description		ribonuclease A family member 1, pancreatic
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GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Nuclease Activity Endonuclease Activity Ribonuclease A Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity
	Biological Process	Defense Response To Gram-positive Bacterium Defense Response To Virus
Pathways		Chaperone Mediated Autophagy Late endosomal microautophagy Developmental Lineage of Pancreatic Acinar Cells
Drugs		Aspartic acid Guanidine Adenosine 3',5'-diphosphate 3'-Phosphate-Adenosine-5'-Diphosphate Formic acid Cytidine 3'-monophosphate Adenosine-2'-5'-Diphosphate 2'-Monophosphoadenosine-5'-Diphosphate 2'-deoxycytidine-2'-deoxyadenosine-3',5'-monophosphate 3'-Uridinemonophosphate Arabinouridine 3'-phosphate Cysteine-S-acetamide 2'-fluoro-2'-deoxyuridine 3'-monophosphate Adenylate-3'-phosphate-[[2'-deoxy-uridine-5'-phosphate]-3'-phosphate] Deoxycytidylyl-3',5'-guanosine Uridylyl-2'-5'-phospho-adenosine 2'-Deoxyuridine 3'-Monophosphate Uridine-2',3'-vanadate Purine Riboside-5'-Monophosphate 2'-cytidylic acid 5-Aminouracil tert-butanol Citric acid N-Formylmethionine Uridylyl-2'-5'-phospho-guanosine 5'-deoxy-5'-piperidin-1-ylthymidine 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: RELA RNH1 TRIM7
Entrez ID		6035
HPRD ID		01591
Ensembl ID		ENSG00000129538
Uniprot IDs		P07998 W0UV93
PDB IDs		1DZA 1E21 1H8X 1Z7X 2E0J 2E0L 2E0M 2E0O 2K11 2Q4G 3F8G 4KXH
Enriched GO Terms of Interacting Partners?		Regulation Of Vasculature Development NF-kappaB P50/p65 Complex Ankyrin Repeat Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Antiviral Innate Immune Response Regulation Of Schwann Cell Differentiation Postsynapse To Nucleus Signaling Pathway Defense Response To Virus Positive Regulation Of Schwann Cell Differentiation Cellular Response To Peptidoglycan Negative Regulation Of Catabolic Process NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Angiogenesis Response To Cobalamin Cellular Response To Nicotine TRNA Stabilization Ribonuclease Inhibitor Activity Angiogenin-PRI Complex Response To Virus Negative Regulation Of Translation In Response To Stress Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipoteichoic Acid Response To Peptidoglycan Phosphate Ion Binding Defense Response To Tumor Cell General Transcription Initiation Factor Binding Negative Regulation Of Protein Sumoylation Actinin Binding Cellular Response To Interleukin-6 Response To Hepatocyte Growth Factor Cellular Response To Angiotensin Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Amyloid-beta Formation Response To Interleukin-6 Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Response To Morphine RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Muramyl Dipeptide Response To UV-B Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Protein Sumoylation Regulation Of Translation In Response To Stress Innate Immune Response Response To Muscle Stretch Negative Regulation Of MiRNA Transcription Interleukin-1-mediated Signaling Pathway
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