RLN2 and RXFP2

Number of citations of the paper that reports this interaction (PMID 12506116)
29

Data Source:
HPRD (in vitro)

		RLN2	RXFP2
Gene Name		relaxin 2	relaxin/insulin-like family peptide receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity	Protein-hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Female Pregnancy	Oocyte Maturation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Apoptotic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: RXFP1 RXFP2	2 interactors: INSL3 RLN2
Entrez ID		6019	122042
HPRD ID		01561	05976
Ensembl ID		ENSG00000107014	ENSG00000133105
Uniprot IDs		P04090	Q8WXD0
PDB IDs		6RLX
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Parturition Oocyte Maturation G-protein Coupled Receptor Signaling Pathway Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Cell Maturation Male Gonad Development Mammary Gland Development Male Sex Differentiation Organ Development Cell Surface Receptor Signaling Pathway Gonad Development Development Of Primary Sexual Characteristics Connective Tissue Development Cell Differentiation Lung Development Germ Cell Development Respiratory Tube Development Respiratory System Development Sex Differentiation	Oocyte Maturation Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Male Gonad Development Male Sex Differentiation
Tagcloud ?			angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory
Tagcloud (Difference) ?			angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory
Tagcloud (Intersection) ?