RXFP2 and RLN2

Number of citations of the paper that reports this interaction (PMID 12506116)
29

Data Source:
HPRD (in vitro)

		RXFP2	RLN2
Gene Name		relaxin/insulin-like family peptide receptor 2	relaxin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Protein-hormone Receptor Activity Peptide Hormone Binding	Hormone Activity
	Biological Process	Oocyte Maturation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Apoptotic Process	Female Pregnancy
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: INSL3 RLN2	2 interactors: RXFP1 RXFP2
Entrez ID		122042	6019
HPRD ID		05976	01561
Ensembl ID		ENSG00000133105	ENSG00000107014
Uniprot IDs		Q8WXD0	P04090
PDB IDs			6RLX
Enriched GO Terms of Interacting Partners?		Oocyte Maturation Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Male Gonad Development Male Sex Differentiation	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Parturition Oocyte Maturation G-protein Coupled Receptor Signaling Pathway Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Cell Maturation Male Gonad Development Mammary Gland Development Male Sex Differentiation Organ Development Cell Surface Receptor Signaling Pathway Gonad Development Development Of Primary Sexual Characteristics Connective Tissue Development Cell Differentiation Lung Development Germ Cell Development Respiratory Tube Development Respiratory System Development Sex Differentiation
Tagcloud ?		angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory
Tagcloud (Difference) ?		angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory
Tagcloud (Intersection) ?