RXFP2 and RLN2

Number of citations of the paper that reports this interaction (PubMedID 15649866)
0

Data Source:
HPRD (in vitro)

		RXFP2	RLN2
Description		relaxin family peptide receptor 2	relaxin 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding	Hormone Activity
	Biological Process	Oocyte Maturation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Signal Transduction Female Pregnancy Positive Regulation Of Gene Expression Positive Regulation Of Angiogenesis Regulation Of Catalytic Activity
Pathways		G alpha (s) signalling events Relaxin receptors	G alpha (s) signalling events Relaxin receptors
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: INSL3 RLN2	2 interacting genes: RXFP1 RXFP2
Entrez ID		122042	6019
HPRD ID		05976	01561
Ensembl ID		ENSG00000133105	ENSG00000107014
Uniprot IDs		Q8WXD0	P04090
PDB IDs		2M96	2MV1 6RLX
Enriched GO Terms of Interacting Partners?		Hormone Activity	G Protein-coupled Peptide Receptor Activity Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Nipple Morphogenesis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Lung Connective Tissue Development G Protein-coupled Receptor Activity Myofibroblast Differentiation Parturition Protein-hormone Receptor Activity Hormone Binding G Protein-coupled Receptor Signaling Pathway Oocyte Maturation Peptide Hormone Binding Reproductive Process Connective Tissue Development Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Male Gonad Development Gonad Development Cell Maturation
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