RXFP2 and INSL3

Number of citations of the paper that reports this interaction (PMID 12114498)
37

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RXFP2	INSL3
Gene Name		relaxin/insulin-like family peptide receptor 2	insulin-like 3 (Leydig cell)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	Protein-hormone Receptor Activity Peptide Hormone Binding	G-protein Coupled Receptor Binding Protease Binding Receptor Binding Insulin Receptor Binding Hormone Activity
	Biological Process	Oocyte Maturation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Apoptotic Process	Oocyte Maturation In Utero Embryonic Development Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Apoptotic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: INSL3 RLN2	1 interactors: RXFP2
Entrez ID		122042	3640
HPRD ID		05976	08854
Ensembl ID		ENSG00000133105	ENSG00000248099
Uniprot IDs		Q8WXD0	P51460
PDB IDs			2H8B 2K6T 2K6U
Enriched GO Terms of Interacting Partners?		Oocyte Maturation Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Male Gonad Development Male Sex Differentiation	Oocyte Maturation Oocyte Development Oocyte Differentiation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Male Gonad Development Male Sex Differentiation Gonad Development Development Of Primary Sexual Characteristics Germ Cell Development Sex Differentiation Reproductive Structure Development Reproductive System Development
Tagcloud ?		angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Difference) ?		angiogenic behaviors chains chronological emerged h2 h3 homeostatic immense intense interact mini native nearly neuropeptide physiology rational relaxin relaxins respective rxfp1 rxfp3 rxfp4 separated subject summarizes superfamily unrelated vasodilatory	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Intersection) ?