RFC5 and RFC2

Number of citations of the paper that reports this interaction (PMID 9228079)
22

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RFC5	RFC2
Gene Name		replication factor C (activator 1) 5, 36.5kDa	replication factor C (activator 1) 2, 40kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex	Nucleus Nucleoplasm DNA Replication Factor C Complex Golgi Apparatus
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Enzyme Binding	DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints	Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: BRD4 CHTF18 COPS6 EEF1A1 LRIF1 MED31 NAB2 PCNA RAD17 RBM48 RFC2 RFC4 TRIM38 UNC119 XIAP	8 interactors: BRD4 PCNA PRKAR1A RAD17 RAD18 RFC1 RFC4 RFC5
Entrez ID		5985	5982
HPRD ID		02677	02675
Ensembl ID		ENSG00000111445	ENSG00000049541
Uniprot IDs		F8W9B4 P40937 Q59GW7	P35250 Q75MT5
PDB IDs		1LFS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Transcription-coupled Nucleotide-excision Repair Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Cellular Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process DNA Repair Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Negative Regulation Of Caveolin-mediated Endocytosis Response To Stress Cytokinesis, Completion Of Separation Chromosome Organization Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Regulation Of Metabolic Process Regulation Of DNA Replication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Caveolin-mediated Endocytosis	Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair Telomere Maintenance DNA Replication Cell Cycle Nucleotide-excision Repair Mitotic Cell Cycle DNA-dependent DNA Replication Cellular Response To Stress Cell Cycle Process DNA Metabolic Process Response To Stress DNA Recombination Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Response To Stimulus Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Metabolic Process Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Regulation Of DNA Replication Cellular Metabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Biosynthetic Process Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4	12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4 rfc5