RFC5 and CHTF18

Number of citations of the paper that reports this interaction (PMID 12930902)
41

Data Source:
BioGRID (pull down)

		RFC5	CHTF18
Gene Name		replication factor C (activator 1) 5, 36.5kDa	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex	Nucleoplasm Cytoplasm Membrane
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Enzyme Binding	DNA Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	DNA Replication Reciprocal Meiotic Recombination Male Meiosis Spermatogenesis Negative Regulation Of Chromosome Segregation
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: BRD4 CHTF18 COPS6 EEF1A1 LRIF1 MED31 NAB2 PCNA RAD17 RBM48 RFC2 RFC4 TRIM38 UNC119 XIAP	4 interactors: PCNA RFC3 RFC4 RFC5
Entrez ID		5985	63922
HPRD ID		02677	13059
Ensembl ID		ENSG00000111445	ENSG00000127586
Uniprot IDs		F8W9B4 P40937 Q59GW7	Q8WVB6
PDB IDs		1LFS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Transcription-coupled Nucleotide-excision Repair Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Cellular Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process DNA Repair Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Negative Regulation Of Caveolin-mediated Endocytosis Response To Stress Cytokinesis, Completion Of Separation Chromosome Organization Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Regulation Of Metabolic Process Regulation Of DNA Replication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Caveolin-mediated Endocytosis	Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication DNA Recombination DNA Replication DNA Repair Cellular Homeostasis Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Chromosome Organization Cell Cycle Process DNA Metabolic Process Cell Cycle Homeostatic Process Cellular Response To Stress DNA Biosynthetic Process Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Organelle Organization Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Translesion Synthesis Cellular Nitrogen Compound Metabolic Process DNA Synthesis Involved In DNA Repair Nitrogen Compound Metabolic Process Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Positive Regulation Of Nuclease Activity Response To Cadmium Ion Mismatch Repair Base-excision Repair Response To Stimulus Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Response To Organophosphorus
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4
Tagcloud (Intersection) ?