RFC5 and NAB2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RFC5	NAB2
Gene Name		replication factor C (activator 1) 5, 36.5kDa	NGFI-A binding protein 2 (EGR1 binding protein 2)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex	Nucleus
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Enzyme Binding	Transcription Corepressor Activity Transcription Factor Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Endochondral Ossification Transcription, DNA-templated Nervous System Development Cell Proliferation Schwann Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase III Promoter Myelination Regulation Of Epidermis Development
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	IgE levels ( 22075330)
Protein-Protein Interactions		15 interactors: BRD4 CHTF18 COPS6 EEF1A1 LRIF1 MED31 NAB2 PCNA RAD17 RBM48 RFC2 RFC4 TRIM38 UNC119 XIAP	33 interactors: AES CCDC33 CCHCR1 CWF19L2 DGCR6 EGR1 EGR2 GCC1 JAKMIP2 KRT40 KRTAP10-3 KRTAP10-8 LENG1 MAPK3 MCM7 MDFI MORF4L1 NEDD9 NME7 NOTCH2NL PHF1 PHOSPHO2 PIN1 RBPMS RFC5 SCNM1 SUMO1P1 TCEANC TCHP TGIF2LY TTC19 ZBED8 ZMYND19
Entrez ID		5985	4665
HPRD ID		02677	03854
Ensembl ID		ENSG00000111445	ENSG00000166886
Uniprot IDs		F8W9B4 P40937 Q59GW7	Q15742
PDB IDs		1LFS
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Replication Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Transcription-coupled Nucleotide-excision Repair Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Cellular Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process DNA Repair Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Negative Regulation Of Caveolin-mediated Endocytosis Response To Stress Cytokinesis, Completion Of Separation Chromosome Organization Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Regulation Of Metabolic Process Regulation Of DNA Replication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Caveolin-mediated Endocytosis	Response To Interleukin-1 Negative Regulation Of Binding Interleukin-1-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Cellular Response To Gonadotropin Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Epidermal Growth Factor RNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Protein Export From Nucleus DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Stress RNA Metabolic Process Response To Gonadotropin Negative Regulation Of Wnt Signaling Pathway Rhombomere 5 Formation Rhombomere 3 Formation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Apolipoprotein Binding Cellular Response To CAMP Nitrogen Compound Metabolic Process Negative Regulation Of Protein Binding Gene Expression Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Interleukin-1 Regulation Of Neuronal Synaptic Plasticity Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Modification Process Cell Cycle Rhombomere 3 Morphogenesis Regulation Of Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Histone Modification BMP Signaling Pathway Brain Segmentation Response To Insulin Regulation Of Growth Regulation Of Wnt Signaling Pathway Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Anoikis Cellular Response To Mycophenolic Acid Regulation Of Golgi Inheritance
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4	atypia dedifferentiated dedifferentiation dfsr dfsrs exclusive exon fibrous formalin fusions harbored hot label mitosis mutually ngfi paraffin pdgfrb pleomorphism sft solitary spot stat6 tert thoracic tp53 transcriptase transducer variations
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc3 rfc4	atypia dedifferentiated dedifferentiation dfsr dfsrs exclusive exon fibrous formalin fusions harbored hot label mitosis mutually ngfi paraffin pdgfrb pleomorphism sft solitary spot stat6 tert thoracic tp53 transcriptase transducer variations
Tagcloud (Intersection) ?