RFC2 and BRD4

Number of citations of the paper that reports this interaction (PMID 12192049)
52

Data Source:
BioGRID (pull down)

		RFC2	BRD4
Gene Name		replication factor C (activator 1) 2, 40kDa	bromodomain containing 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Golgi Apparatus	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Positive Transcription Elongation Factor Complex B
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding	P53 Binding DNA Binding Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation Chromatin Remodeling Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Histone H4-K12 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of DNA Damage Checkpoint
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BRD4 PCNA PRKAR1A RAD17 RAD18 RFC1 RFC4 RFC5	18 interactors: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 HIST2H3C HIST2H4A HIST4H4 JMJD6 MESDC2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 TCERG1
Entrez ID		5982	23476
HPRD ID		02675	10574
Ensembl ID		ENSG00000049541	ENSG00000141867
Uniprot IDs		P35250 Q75MT5	O60885
PDB IDs			2I8N 2LSP 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4KV1 4KV4 4LR6 4LRG 4MEN 4MEO 4MEP 4MEQ
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair Telomere Maintenance DNA Replication Cell Cycle Nucleotide-excision Repair Mitotic Cell Cycle DNA-dependent DNA Replication Cellular Response To Stress Cell Cycle Process DNA Metabolic Process Response To Stress DNA Recombination Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Response To Stimulus Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Metabolic Process Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Regulation Of DNA Replication Cellular Metabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation Biosynthetic Process Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process	Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleotide-excision Repair DNA-dependent DNA Replication Mitotic Cell Cycle Homeostatic Process DNA Methylation On Cytosine Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Chromatin Silencing Histone Demethylation Protein Demethylation Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Organelle Organization DNA Methylation Demethylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly DNA Modification Cellular Metabolic Process DNA Repair Cell Cycle Process Gene Silencing Cellular Homeostasis Regulation Of Megakaryocyte Differentiation Gene Expression Cell Division CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process
Tagcloud ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Difference) ?		12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc3 rfc4 rfc5	3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Intersection) ?