PMAIP1

Name	phorbol-12-myristate-13-acetate-induced protein 1
Structure
Interactors	13 interactors: BAX BCL2 BCL2A1 BCL2L1 GSK3B MCL1 PPBP RAB2A RNF7 STUB1 UBE2D1 UBE2D2 ZBTB16
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Glucose Starvation T Cell Homeostasis Positive Regulation Of Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways	Activation of NOXA and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
GWAS	Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 23669352 26426971 28892062 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Coronary artery disease ( 33020668 26343387 ) HDL cholesterol levels ( 32203549 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) Metabolic syndrome ( 20694148 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Regular attendance at a pub or social club ( 29970889 ) Restless legs syndrome ( 33239738 ) Schizophrenia x sex interaction ( 34099189 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Entrez ID	5366
HPRD ID	12002
Ensembl ID	ENSG00000141682
Uniprot IDs	A0A0S2Z490 A0A0S2Z4V2 Q13794
PDB IDs	3MQP
GO Terms Enriched among Interactors ?	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand BH3 Domain Binding Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Channel Activity Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Apoptotic Mitochondrial Changes Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrial Outer Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Response To Endoplasmic Reticulum Stress Programmed Cell Death Involved In Cell Development Negative Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Anoikis Negative Regulation Of Apoptotic Process Mitochondrial Membrane Organization Negative Regulation Of Programmed Cell Death Protein Polyubiquitination Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Organelle Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Ubiquitination Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Autophagy Leukocyte Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Gamma Radiation