PMAIP1

Gene Name		phorbol-12-myristate-13-acetate-induced protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To UV Response To X-ray Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Oligomerization Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Fibroblast Proliferation Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of NOXA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Body mass index ( 23669352) Metabolic syndrome ( 20694148)
Protein-protein Interactions		9 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 GSK3B MCL1 PPBP ZBTB16
Entrez ID		5366
HPRD ID		12002
Ensembl ID		ENSG00000141682
Uniprot IDs		Q13794 Q8N589
PDB IDs		3MQP
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Cell Death Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Negative Regulation Of Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Death Apoptotic Mitochondrial Changes Negative Regulation Of Signal Transduction Negative Regulation Of Anoikis Positive Regulation Of Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Signaling Regulation Of Mitochondrion Organization Regulation Of Anoikis Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress Cellular Response To DNA Damage Stimulus Male Gonad Development Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Nitrogen Utilization Regulation Of Intracellular Signal Transduction Male Sex Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Sertoli Cell Proliferation Response To Gamma Radiation Cell Surface Receptor Signaling Pathway Neuron Apoptotic Process Gonad Development Development Of Primary Sexual Characteristics
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly sqstm1 sy5y trp53 unmask