NLRP4

Gene Name		NLR family, pyrin domain containing 4
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	ATP Binding
	Biological Process	Inflammatory Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response
Pathways		ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: CHUK NLRC4
Entrez ID		147945
HPRD ID		09619
Ensembl ID		ENSG00000160505
Uniprot IDs		B2RCA1 Q96MN2
PDB IDs		4EWI
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1 Beta Secretion Inflammatory Response Response To Bacterium Pyroptosis Interleukin-1 Secretion Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Secretion Positive Regulation Of Immune Response Response To Other Organism Response To Biotic Stimulus Interleukin-1 Beta Production Innate Immune Response I-kappaB Phosphorylation Regulation Of Immune Response Positive Regulation Of Immune System Process Mitotic Spindle Assembly Detection Of Bacterium Mammary Gland Epithelial Cell Proliferation Response To Hydroperoxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Detection Of Biotic Stimulus Skeletal Muscle Contraction Cytokine Secretion Immune Response Regulation Of Immune System Process Defense Response Mitotic Spindle Organization Musculoskeletal Movement Mammary Gland Alveolus Development Mammary Gland Lobule Development Osteoclast Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lactation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Rho Protein Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Morphogenesis Of An Epithelial Sheet TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		aureus chordates confirming cystine deleterious drosophila equivalent evolutionarily exoproteins immunity killing knot neutrophil ngfbeta nlrp3 phagocytosis proinflammatory released shared spaetzle staphylococcus structurally superoxide toll trka tropomyosin unexpected vertebrate zebrafish