NLRP4

Description		NLR family pyrin domain containing 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Inflammatory Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response Protein K33-linked Deubiquitination
Pathways		IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Plasma anti-thyroglobulin levels ( 29678681)
Interacting Genes		2 interacting genes: CHUK NLRC4
Entrez ID		147945
HPRD ID		09619
Ensembl ID		ENSG00000160505
Uniprot IDs		B2RCA1 Q96MN2
PDB IDs		4EWI
Enriched GO Terms of Interacting Partners?		Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Acetate Positive Regulation Of DNA-binding Transcription Factor Activity Activation Of Innate Immune Response Response To Cholecystokinin Positive Regulation Of Innate Immune Response IkappaB Kinase Activity IPAF Inflammasome Complex Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Cytokine Production IkappaB Kinase Complex Inflammatory Response CD40 Receptor Complex Transferrin Receptor Binding Detection Of Bacterium Positive Regulation Of Immune Response Innate Immune Response Caspase Binding Protein Homodimerization Activity Canonical Inflammasome Complex Defense Response To Symbiont Defense Response To Other Organism Endopeptidase Activator Activity Regulation Of Cytokine Production Regulation Of Defense Response Response To Hydroperoxide Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Regulation Of Immune Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Detection Of Biotic Stimulus Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Contraction Response To Other Organism Immune Response Positive Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Pyroptotic Inflammatory Response Icosanoid Biosynthetic Process Cell Surface Toll-like Receptor Signaling Pathway Response To External Biotic Stimulus
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