PPP1R3B and PLCE1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		PPP1R3B	PLCE1
Description		protein phosphatase 1 regulatory subunit 3B	phospholipase C epsilon 1
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Glycogen Granule	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Enzyme Binding [phosphorylase] Phosphatase Activity Glycogen Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process	Lipid Metabolic Process Diacylglycerol Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol
Pathways			Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee or tea ( 33287642) Cholesterol, total ( 25961943 20686565 24097068) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 20686565 21347282 23505323 23726366 25961943 24097068) HDL cholesterol levels ( 28334899) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 20686565 20864672 25961943 24097068) LDL cholesterol levels ( 28334899) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver volume ( 34128465) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cataracts ( 34127677) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 21909115 27841878 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Glucose homeostasis traits ( 25524916) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertension ( 31879980 21909115) Language functional connectivity ( 34929384) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27322543 27182965) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 27863252 32888494) Pulse pressure ( 28739976 27841878 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976 21909115 30578418 27841878 27618452) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PRKAB2 PYGB PYGM	5 interacting genes: HRAS KIT LIMS1 NRAS PPP1R3B
Entrez ID		79660	51196
HPRD ID		17894	07087
Ensembl ID		ENSG00000173281	ENSG00000138193
Uniprot IDs		Q86XI6	A0A8I5KXT2 B7ZM61 Q9P212
PDB IDs		2EEF 5ZT0	2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity PTW/PP1 Phosphatase Complex Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Glycogen Catabolic Process Entrainment Of Circadian Clock By Photoperiod Polysaccharide Catabolic Process Photoperiodism Entrainment Of Circadian Clock Pyridoxal Phosphate Binding Circadian Regulation Of Gene Expression Phosphatase Activity Myosin-light-chain-phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Kinase Binding Type I Interferon Receptor Activity Type I Interferon Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Circadian Rhythm Carbohydrate Catabolic Process JAK Pathway Signal Transduction Adaptor Activity Dephosphorylation Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Phosphoprotein Phosphatase Activity Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Diacylglycerol Biosynthetic Process Chromosome, Telomeric Region Glycogen Granule AMP-activated Protein Kinase Activity Glycosyltransferase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Rhythmic Process Nucleotide-activated Protein Kinase Complex Extracellular Exosome Phospholipase C Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex	Regulation Of Epithelial Cell Proliferation Regulation Of Neuronal Synaptic Plasticity GDP Binding G Protein Activity Regulation Of Long-term Neuronal Synaptic Plasticity Ras Protein Signal Transduction Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GTPase Complex Calcium:proton Antiporter Activity Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Phospholipase C Activator Activity Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Regulation Of Generation Of Precursor Metabolites And Energy Calcium Export From The Mitochondrion Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mitochondrial Potassium Ion Transmembrane Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Metabolic Process Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Cell Projection Assembly Cell Death Regulation Of Synaptic Plasticity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Oncogene-induced Cell Senescence Negative Regulation Of Programmed Cell Death Programmed Cell Death MAPK Cascade Myeloid Progenitor Cell Differentiation Tongue Development Cell-cell Junction Germ Cell Migration Hematopoietic Stem Cell Migration Regulation Of Mast Cell Proliferation Mast Cell Migration Glycogen Granule Regulation Of Glycogen Catabolic Process
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