GBA3 and PRKCSH

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GBA3	PRKCSH
Name		glucosylceramidase beta 3 (gene/pseudogene)	PRKCSH beta subunit of glucosidase II
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Catalytic Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Galactosylceramidase Activity Glucosylceramidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-galactosidase Activity Protein Binding Beta-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glycosylceramidase Activity	Protein Kinase C Binding Calcium Ion Binding Protein Binding Transmembrane Transporter Binding Metal Ion Binding Phosphoprotein Binding
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Glucosylceramide Catabolic Process Galactosylceramide Catabolic Process Oligosaccharide Catabolic Process Carbohydrate Catabolic Process Glycoside Catabolic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Protein Stabilization Beta-glucoside Catabolic Process Positive Regulation Of Exo-alpha-sialidase Activity	Liver Development N-glycan Processing Intracellular Signal Transduction
Pathways		Glycosphingolipid catabolism	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Diseases		None	Polycystic liver disease
GWAS		Ankylosing spondylitis ( 30946743 ) Anti-saccade response ( 29064472 ) Fasting glucose ( 33381925 ) Manganese levels ( 26025379 ) Metabolite levels ( 23823483 ) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627 ) Rosacea symptom severity ( 29771307 ) Serum metabolite levels ( 23093944 33031748 ) Tourette's syndrome or obsessive-compulsive disorder ( 25158072 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )	Presence of antiphospholipid antibodies ( 27098658 ) Serum metabolite levels (CMS) ( 31636271 )
Novel Interactors		None recorded	1 novel interactors: SMARCA4
Interacting Genes		2 interacting genes: PRKCSH TNS2	11 interacting genes: ARL4D CANX ESR1 FXR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		57733	5589
HPRD ID		09428	03518
Ensembl ID		ENSG00000249948	ENSG00000130175
Uniprot IDs		A8K9N1 B7Z536 Q9H227	B4DJQ5 K7ELL7 P14314
PDB IDs		2E9L 2E9M 2JFE 2ZOX 3VKK	8D43 8EMR
GO Terms Enriched among Interactors		Glucosidase II Complex	Maternal Process Involved In Female Pregnancy Mammary Gland Branching Involved In Pregnancy Nucleolus Branching Involved In Mammary Gland Duct Morphogenesis Nuclear Steroid Receptor Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Membrane RNA Binding ERAD Pathway Presynapse Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Transcription Preinitiation Complex Assembly TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Transcription Coregulator Binding Regulation Of MiRNA Transcription Positive Regulation Of Catalytic Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of MiRNA Metabolic Process Developmental Process Involved In Reproduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Biosynthetic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity Antral Ovarian Follicle Growth Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Cell Differentiation DN2 Thymocyte Differentiation Plasma Membrane Raft Distribution Cytoplasmic Side Of Plasma Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Response To Alcohol Membrane Microdomain Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Glycine Import Across Plasma Membrane Adenylate Cyclase Inhibitor Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Cytoplasmic Ribonucleoprotein Granule