SLAIN2 and SGO2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		SLAIN2	SGO2
Description		SLAIN motif family member 2	shugoshin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Cytoskeleton Microtubule Plus-end	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body Mitotic Cohesin Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Microtubule Nucleation Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization	Chromosome Segregation Meiotic Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Uterine fibroids ( 30194396)
Interacting Genes		12 interacting genes: APP CASK CEBPA CKAP5 DAPK1 MAPRE2 PTPRD SGO2 SMURF1 SRPK1 SRPK2 TULP3	7 interacting genes: CDCA8 EXOSC8 PPP2CA PPP2R1A PPP2R1B SET SLAIN2
Entrez ID		57606	151246
HPRD ID		13863	11555
Ensembl ID		ENSG00000109171	ENSG00000163535
Uniprot IDs		A0A024R9T6 Q9P270	B7Z7S9 Q562F6
PDB IDs		3RDV
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Microtubule Plus-end Microtubule Plus-end Binding Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleolus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Kinase Activity Protein Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Microtubule Plus End Polymerase Engulfment Of Target By Autophagosome Positive Regulation Of Viral Process Acetylcholine Receptor Activator Activity PTB Domain Binding Signaling Receptor Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Binding Defense Response Cell Surface Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Cell Differentiation Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Signal Transduction Astrocyte Activation Involved In Immune Response Microglia Development	Protein Phosphatase Type 2A Complex RNA Surveillance Nuclear RNA Surveillance Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion, Centromeric Microtubule Cytoskeleton Spindle Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion INTAC Complex FAR/SIN/STRIPAK Complex Microtubule Cytoskeleton Organization RNA Polymerase II Transcription Initiation Surveillance Chromosome, Centromeric Region Spindle Organization Negative Regulation Of Hippo Signaling RNA Catabolic Process T Cell Homeostasis Chromosome Sister Chromatid Cohesion Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Membraneless Organelle Assembly DNA-templated Transcription Elongation Microtubule-based Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Nucleobase-containing Compound Catabolic Process Regulation Of Microtubule Polymerization RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Chromosome Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Leukocyte Homeostasis Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Regulation Of Microtubule Polymerization Or Depolymerization U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Mitotic Cell Cycle Cytosol Chromosome Segregation Positive Regulation Of Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Mitotic Sister Chromatid Separation
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