SLAIN2 and CKAP5

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology)

		SLAIN2	CKAP5
Description		SLAIN motif family member 2	cytoskeleton associated protein 5
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Cytoskeleton Microtubule Plus-end	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Mitotic Spindle
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Tubulin Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase
	Biological Process	Microtubule Nucleation Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein-containing Complex Organization Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Uterine fibroids ( 30194396)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)
Interacting Genes		12 interacting genes: APP CASK CEBPA CKAP5 DAPK1 MAPRE2 PTPRD SGO2 SMURF1 SRPK1 SRPK2 TULP3	16 interacting genes: ARHGEF16 AURKA CACNA1A CEBPA CLASP1 CLK1 DYRK1A HSPA13 NDC80 OLIG2 PTPRN2 SLAIN2 SUMO2 TOP1 TTC3 USP19
Entrez ID		57606	9793
HPRD ID		13863	10830
Ensembl ID		ENSG00000109171	ENSG00000175216
Uniprot IDs		A0A024R9T6 Q9P270	Q14008
PDB IDs		3RDV	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Microtubule Plus-end Microtubule Plus-end Binding Positive Regulation Of Proteolysis Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleolus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Kinase Activity Protein Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Microtubule Plus End Polymerase Engulfment Of Target By Autophagosome Positive Regulation Of Viral Process Acetylcholine Receptor Activator Activity PTB Domain Binding Signaling Receptor Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus G Protein-coupled Receptor Binding Defense Response Cell Surface Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Cell Differentiation Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Signal Transduction Astrocyte Activation Involved In Immune Response Microglia Development	Protein Serine/threonine/tyrosine Kinase Activity Spindle Assembly Involved In Female Meiosis I Animal Organ Regeneration Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process HMG Box Domain Binding Regulation Of Microtubule-based Process Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regeneration Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Plus-end Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Microtubule Nucleation Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Cell Cycle Phase Transition Kinetochore Positive Regulation Of Microtubule Polymerization Regulation Of Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Peptidyl-serine Phosphorylation Spindle Microtubule Microtubule Cytoskeleton Organization Cell Division Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Histone H3T45 Kinase Activity Kinetochore Adaptor Activity Centrosomal Corona Regulation Of Cytoskeleton Organization Establishment Of Spindle Localization
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