MIB1 and CEP131

Number of citations of the paper that reports this interaction (PMID 24121310)
4

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MIB1	CEP131
Gene Name		mindbomb E3 ubiquitin protein ligase 1	centrosomal protein 131kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle	Acrosomal Vesicle Nucleus Nucleoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Nuclear Membrane Centriolar Satellite Cell Projection Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Molecular_function Protein Binding Protein Complex Binding Protein Homodimerization Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Multicellular Organismal Development Spermatogenesis Positive Regulation Of Cell Proliferation Regulation Of Centrosome Duplication Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Intracellular Protein Transport
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AZI2 BLM CEP131 DAB2 DAPK1 SNX5 TBK1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	2 interactors: MIB1 PCM1
Entrez ID		57534	22994
HPRD ID		06660	16532
Ensembl ID		ENSG00000101752	ENSG00000141577
Uniprot IDs		Q86YT6	I3L2J8 Q9UPN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Dendritic Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune System Process Cellular Response To Stress Protein Catabolic Process Response To Stress Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process DNA Double-strand Break Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process DNA Repair Pinocytosis Positive Regulation Of Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Catabolic Process Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Defense Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Cellular Response To Stimulus	Negative Regulation Of Neurogenesis Negative Regulation Of Cell Development Intraciliary Transport Involved In Cilium Morphogenesis Microtubule Anchoring At Centrosome Regulation Of Neurogenesis Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Cell Differentiation Positive Regulation Of Transport Protein Localization To Centrosome Regulation Of Cell Development Interkinetic Nuclear Migration Protein Localization To Cytoskeleton Neuronal Stem Cell Maintenance Anatomical Structure Formation Involved In Morphogenesis Intraciliary Transport Cytoplasmic Microtubule Organization Nucleus Localization Cell Proliferation In Forebrain Generation Of Neurons Regulation Of Cell Differentiation Microtubule Anchoring Neurogenesis Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Somitogenesis Embryonic Heart Tube Development Somite Development Centrosome Organization Positive Regulation Of Endocytosis Neural Precursor Cell Proliferation Determination Of Left/right Symmetry Microtubule Organizing Center Organization Nervous System Development Determination Of Bilateral Symmetry Segmentation G2/M Transition Of Mitotic Cell Cycle Anatomical Structure Morphogenesis Neural Tube Formation Microtubule-based Transport Notch Signaling Pathway Cytoskeleton-dependent Intracellular Transport Maintenance Of Protein Location In Cell Embryonic Epithelial Tube Formation Epithelial Tube Formation Maintenance Of Protein Location Stem Cell Maintenance Maintenance Of Location In Cell Positive Regulation Of Intracellular Protein Transport Tube Formation
Tagcloud ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken
Tagcloud (Difference) ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken
Tagcloud (Intersection) ?