PRR12 and PUM1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRR12	PUM1
Description		proline rich 12	pumilio RNA binding family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Postsynaptic Density Neuron Projection Synapse	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Axon
	Molecular Function		RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process		Regulation Of Translation Spermatogenesis Adult Locomotory Behavior Post-transcriptional Regulation Of Gene Expression Post-transcriptional Gene Silencing Cell Differentiation MiRNA Processing Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Fibrinogen levels ( 26561523) HDL cholesterol levels ( 32203549) Hodgkin's lymphoma ( 34216518) Schizophrenia ( 25056061 29483656) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		2 interacting genes: FASN PUM1	48 interacting genes: ATXN1 COPS5 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1
Entrez ID		57479	9698
HPRD ID		19620	06230
Ensembl ID		ENSG00000126464	ENSG00000134644
Uniprot IDs		Q9ULL5	Q14671
PDB IDs			1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?		Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding 3-oxoacyl-[acyl-carrier-protein] Synthase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Glycogen Granule Ether Lipid Biosynthetic Process Neutrophil Differentiation Response To Caloric Restriction Positive Regulation Of MiRNA-mediated Gene Silencing Positive Regulation Of RIG-I Signaling Pathway Establishment Of Endothelial Intestinal Barrier 3'-UTR-mediated MRNA Destabilization Monocyte Differentiation Regulation Of RIG-I Signaling Pathway Ether Lipid Metabolic Process Granulocyte Differentiation Fatty-acyl-CoA Biosynthetic Process Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Acetyl-CoA Metabolic Process Mammary Gland Development Establishment Of Endothelial Barrier MiRNA Binding MiRNA Processing Endothelial Cell Development Fatty Acid Derivative Biosynthetic Process Positive Regulation Of Pattern Recognition Receptor Signaling Pathway RNA Binding Host-mediated Perturbation Of Viral Process Fatty Acid Derivative Metabolic Process Adult Locomotory Behavior Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Melanosome MRNA Destabilization RNA Destabilization P-body Cytoplasmic Stress Granule Host-mediated Perturbation Of Symbiont Process Stem Cell Differentiation Positive Regulation Of MRNA Catabolic Process Fatty Acid Biosynthetic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Locomotion Regulation Of MRNA Stability Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication
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