PRR12 and FASN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRR12	FASN
Description		proline rich 12	fatty acid synthase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Postsynaptic Density Neuron Projection Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome
	Molecular Function		RNA Binding Catalytic Activity Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Protein Binding Fatty Acyl-[ACP] Hydrolase Activity Oxidoreductase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lyase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity
	Biological Process		Osteoblast Differentiation Epithelial Cell Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Response To Nutrient Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Tissue Development Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Response To Nutrient Levels Host-mediated Perturbation Of Viral Process Fatty-acyl-CoA Biosynthetic Process Response To Caloric Restriction Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways			ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs			Cerulenin Orlistat
Diseases
GWAS		Fibrinogen levels ( 26561523) HDL cholesterol levels ( 32203549) Hodgkin's lymphoma ( 34216518) Schizophrenia ( 25056061 29483656) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: FASN PUM1	16 interacting genes: ADIPOQ AKT1 CEBPA CRYAA DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN RPF1 SNX8 SUMO2 YWHAQ
Entrez ID		57479	2194
HPRD ID		19620	02567
Ensembl ID		ENSG00000126464	ENSG00000169710
Uniprot IDs		Q9ULL5	P49327
PDB IDs			1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA 7MHD 7MHE 8EYI 8EYK 8G7X 8GKC 8VF7 8VG4 8VLE 8VLO 8VLP 8VM0 8VM5 8VM6 8VM7 8VMC 8VMD 9B7Z 9B80 9MJ9
Enriched GO Terms of Interacting Partners?		Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding 3-oxoacyl-[acyl-carrier-protein] Synthase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Glycogen Granule Ether Lipid Biosynthetic Process Neutrophil Differentiation Response To Caloric Restriction Positive Regulation Of MiRNA-mediated Gene Silencing Positive Regulation Of RIG-I Signaling Pathway Establishment Of Endothelial Intestinal Barrier 3'-UTR-mediated MRNA Destabilization Monocyte Differentiation Regulation Of RIG-I Signaling Pathway Ether Lipid Metabolic Process Granulocyte Differentiation Fatty-acyl-CoA Biosynthetic Process Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Acetyl-CoA Metabolic Process Mammary Gland Development Establishment Of Endothelial Barrier MiRNA Binding MiRNA Processing Endothelial Cell Development Fatty Acid Derivative Biosynthetic Process Positive Regulation Of Pattern Recognition Receptor Signaling Pathway RNA Binding Host-mediated Perturbation Of Viral Process Fatty Acid Derivative Metabolic Process Adult Locomotory Behavior Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Melanosome MRNA Destabilization RNA Destabilization P-body Cytoplasmic Stress Granule Host-mediated Perturbation Of Symbiont Process Stem Cell Differentiation Positive Regulation Of MRNA Catabolic Process Fatty Acid Biosynthetic Process	Identical Protein Binding Myelin Maintenance Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Catabolic Process Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteolysis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Nucleus Regulation Of Gene Expression Response To Heat Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Synapse Maturation Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Proteasomal Protein Catabolic Process Plasma Membrane Organization Response To Decreased Oxygen Levels Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Response To Oxygen Levels Protein Refolding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Peptidyl-serine Phosphorylation Reactive Nitrogen Species Metabolic Process Response To Temperature Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation 14-3-3 Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Brown Fat Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Homodimerization Activity
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