PRR12 and FASN

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRR12	FASN
Gene Name		proline rich 12	fatty acid synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Vesicular Exosome
	Molecular Function	DNA Binding	Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH, B-specific) Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding Drug Binding Zinc Ion Binding Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Protein Homodimerization Activity Poly(A) RNA Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity NADPH Binding
	Biological Process		Osteoblast Differentiation Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Pantothenate Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Response To Interleukin-4
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs			Cerulenin Orlistat
Diseases
GWAS
Protein-Protein Interactions		2 interactors: FASN PUM1	4 interactors: EWSR1 NDRG1 PRR12 YWHAQ
Entrez ID		57479	2194
HPRD ID		19620	02567
Ensembl ID		ENSG00000126464	ENSG00000169710
Uniprot IDs		Q9ULL5	P49327
PDB IDs			1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM
Enriched GO Terms of Interacting Partners?		Pantothenate Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Cellular Response To Interleukin-4 Triglyceride Biosynthetic Process Response To Interleukin-4 Acyl-CoA Metabolic Process Water-soluble Vitamin Metabolic Process Post-Golgi Vesicle-mediated Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Vitamin Metabolic Process Fatty Acid Biosynthetic Process Energy Reserve Metabolic Process Osteoblast Differentiation Coenzyme Biosynthetic Process	Positive Regulation Of Spindle Checkpoint Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Spindle Checkpoint Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Myelin Maintenance Membrane Organization Mast Cell Activation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Substantia Nigra Development
Tagcloud ?			acc adipose adiposity carboxylase coa conceivable db depot dio distension distortion epidemiologic follicular hypofunction hypothyroidism intrathyroidal lipogenesis ob obese peroxisome proliferator srebp steatosis sterol synthetase systemically thyroid ultrastructural uniformly
Tagcloud (Difference) ?			acc adipose adiposity carboxylase coa conceivable db depot dio distension distortion epidemiologic follicular hypofunction hypothyroidism intrathyroidal lipogenesis ob obese peroxisome proliferator srebp steatosis sterol synthetase systemically thyroid ultrastructural uniformly
Tagcloud (Intersection) ?