PLCL2 and DSCAML1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PLCL2	DSCAML1
Description		phospholipase C like 2	DS cell adhesion molecule like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Space Plasma Membrane Cell Surface Membrane Axon Synapse
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Binding Phosphoric Diester Hydrolase Activity GABA Receptor Binding Inositol 1,4,5 Trisphosphate Binding	Protein Homodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Lipid Metabolic Process Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cold-induced Thermogenesis	Cell Fate Determination Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axonogenesis Axon Guidance Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance
Pathways			DSCAM interactions
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 32296059) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive ability (MTAG) ( 29186694) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Intelligence ( 28530673) Lung cancer ( 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 29403010 28017375 27863252) Mean corpuscular volume ( 28017375 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mood instability ( 31168069) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Myocardial infarction ( 24916648) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neurociticism ( 29500382) Primary biliary cholangitis ( 21399635 26394269) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Smoking initiation ( 33082346) Sum eosinophil basophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lipoprotein (a) - cholesterol levels ( 25575512) Menarche (age at onset) ( 23599027) Myopia ( 27182965) Putamen volume ( 29147026) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 28548082) Triglycerides ( 19074352 30275531) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		2 interacting genes: DSCAML1 PPP1CA	4 interacting genes: DYRK1A MAGI2 MAGI3 PLCL2
Entrez ID		23228	57453
HPRD ID		07147	10921
Ensembl ID		ENSG00000154822	ENSG00000177103
Uniprot IDs		Q9UPR0	A0A384DVL8 Q8TD84
PDB IDs			1VA9
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Translational Initiation In Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Transition Metal Ion Binding Entrainment Of Circadian Clock By Photoperiod Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Cell Adhesion Regulation Of Translation In Response To Stress Response To Lead Ion Negative Regulation Of Transcription Elongation By RNA Polymerase II Dendrite Self-avoidance Protein Phosphatase 1 Binding Negative Regulation Of DNA-templated Transcription, Elongation Photoperiodism Entrainment Of Circadian Clock Regulation Of Glycogen Biosynthetic Process Ribonucleoprotein Complex Binding Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Glycogen Metabolic Process Cell-cell Adhesion Mediator Activity Cell Fate Determination Positive Regulation Of Glucose Metabolic Process Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Recognition Glycogen Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Nonhomologous End Joining DNA-templated Transcription Elongation Anatomical Structure Morphogenesis Animal Organ Development Positive Regulation Of Transcription Elongation By RNA Polymerase II Circadian Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Carbohydrate Catabolic Process Dorsal/ventral Pattern Formation Energy Reserve Metabolic Process Polysaccharide Metabolic Process	Negative Regulation Of Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Phosphate-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Negative Regulation Of Signaling Splicing Factor Binding Regulation Of Heterochromatin Formation Histone H3T45 Kinase Activity Podocyte Development Cell-cell Junction Beta-1 Adrenergic Receptor Binding Slit Diaphragm Type II Activin Receptor Binding Bicellular Tight Junction B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway B-1 B Cell Differentiation GMP Kinase Activity GDP Metabolic Process Inositol 1,4,5 Trisphosphate Binding Negative Regulation Of Microtubule Polymerization Nerve Growth Factor Signaling Pathway Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Activin Receptor Signaling Pathway GABA Receptor Binding Dendrite Intracellular Signal Transduction Tau-protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Nervous System Development Negative Regulation Of RNA Splicing Regulation Of Inclusion Body Assembly Neurotrophin Signaling Pathway Positive Regulation Of Receptor Internalization SMAD Protein Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Gamma-aminobutyric Acid Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity GMP Metabolic Process Clathrin-dependent Endocytosis Signaling Receptor Complex Adaptor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?