PLCL2

Description		phospholipase C like 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Binding Phosphoric Diester Hydrolase Activity GABA Receptor Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Lipid Metabolic Process Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 32296059) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive ability (MTAG) ( 29186694) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Intelligence ( 28530673) Lung cancer ( 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 29403010 28017375 27863252) Mean corpuscular volume ( 28017375 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mood instability ( 31168069) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Myocardial infarction ( 24916648) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neurociticism ( 29500382) Primary biliary cholangitis ( 21399635 26394269) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Smoking initiation ( 33082346) Sum eosinophil basophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023)
Interacting Genes		2 interacting genes: DSCAML1 PPP1CA
Entrez ID		23228
HPRD ID		07147
Ensembl ID		ENSG00000154822
Uniprot IDs		Q9UPR0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Translational Initiation In Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Transition Metal Ion Binding Entrainment Of Circadian Clock By Photoperiod Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Cell Adhesion Regulation Of Translation In Response To Stress Response To Lead Ion Negative Regulation Of Transcription Elongation By RNA Polymerase II Dendrite Self-avoidance Protein Phosphatase 1 Binding Negative Regulation Of DNA-templated Transcription, Elongation Photoperiodism Entrainment Of Circadian Clock Regulation Of Glycogen Biosynthetic Process Ribonucleoprotein Complex Binding Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Glycogen Metabolic Process Cell-cell Adhesion Mediator Activity Cell Fate Determination Positive Regulation Of Glucose Metabolic Process Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Recognition Glycogen Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Nonhomologous End Joining DNA-templated Transcription Elongation Anatomical Structure Morphogenesis Animal Organ Development Positive Regulation Of Transcription Elongation By RNA Polymerase II Circadian Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Carbohydrate Catabolic Process Dorsal/ventral Pattern Formation Energy Reserve Metabolic Process Polysaccharide Metabolic Process
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