DOCK10 and RHOJ

Number of citations of the paper that reports this interaction (PubMedID 15710388)
0

Data Source:
HPRD (in vitro)

		DOCK10	RHOJ
Description		dedicator of cytokinesis 10	ras homolog family member J
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase-mediated Signal Transduction Regulation Of Cell Migration Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis Regulation Of Postsynapse Assembly	Angiogenesis Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Establishment Of Cell Polarity Actin Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production	RHOJ GTPase cycle
Drugs
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)	Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: CCDC102B CFTR LURAP1 MAGEA11 RHOJ	22 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS ZNF426
Entrez ID		55619	57381
HPRD ID		10919	09632
Ensembl ID		ENSG00000135905	ENSG00000126785
Uniprot IDs		A0A2R8YD85 Q96BY6	Q7Z513 Q9H4E5
PDB IDs		6TKY 6TKZ 6TM1 7Q43
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Centriole-centriole Cohesion Golgi-associated Vesicle Membrane Cellular Response To Forskolin	SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Protein Serine/threonine Kinase Activity Anatomical Structure Morphogenesis Cell Migration Ameboidal-type Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Cell Projection Morphogenesis Neuron Projection Morphogenesis I-SMAD Binding Dendritic Spine Morphogenesis Protein Kinase Activity Regulation Of Cell Motility Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Motility Roof Of Mouth Development Regulation Of Locomotion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Activin Responsive Factor Complex Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Kinase Activity Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Migration Ventricular Septum Morphogenesis Regulation Of Actin Filament Organization Positive Regulation Of SMAD Protein Signal Transduction Tissue Development Neuron Projection Organization Postsynapse Organization Gastrulation Activin Receptor Complex Activin Receptor Activity, Type I SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of Stress Fiber Assembly
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