DOCK10 and LURAP1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DOCK10	LURAP1
Description		dedicator of cytokinesis 10	leucine rich adaptor protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase-mediated Signal Transduction Regulation Of Cell Migration Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis Regulation Of Postsynapse Assembly	Positive Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)	Body mass index ( 26426971)
Interacting Genes		5 interacting genes: CCDC102B CFTR LURAP1 MAGEA11 RHOJ	21 interacting genes: ABI2 BLOC1S6 CCDC112 CCDC185 CSNK1D DOCK10 DTNB HAUS1 HGS HMG20A HUNK KRT3 PRPF31 SHFL SNAP29 TCEANC THAP7 TPM3 U2AF2 ZNF417 ZNF821
Entrez ID		55619	541468
HPRD ID		10919	18478
Ensembl ID		ENSG00000135905	ENSG00000171357
Uniprot IDs		A0A2R8YD85 Q96BY6	Q96LR2
PDB IDs		6TKY 6TKZ 6TM1 7Q43
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Centriole-centriole Cohesion Golgi-associated Vesicle Membrane Cellular Response To Forskolin
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