PSMD2 and CCT2

Number of citations of the paper that reports this interaction (PubMedID 23190606)
49

Data Source:
BioGRID (pull down)

		PSMD2	CCT2
Description		proteasome 26S subunit ubiquitin receptor, non-ATPase 2	chaperonin containing TCP1 subunit 2
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GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Proteasome Storage Granule Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Zona Pellucida Receptor Complex Extracellular Region Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Azurophil Granule Lumen Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Regulator Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Chaperone-mediated Protein Complex Assembly ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 29273807)	Height ( 18391951) Logical memory (delayed recall) in normal cognition ( 29274321) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		31 interacting genes: ADRM1 BAG1 CALM1 CCT2 DSCAM DSCR9 FAF2 FKBP8 LINC01554 LRIF1 MTNR1A NDRG1 NUB1 PSMB4 PSMC1 PSMC2 PSMD5 PTN STEAP1 STUB1 TBC1D3B TBC1D3G TNFRSF1A UBD UBE3C UBLCP1 UNC119 USP14 VPS9D1 ZBTB16 ZBTB39	27 interacting genes: ACTA1 ACTB AKT1 CEBPA ERLIN2 ESR1 FCHSD2 GABARAP GABARAPL1 GLI1 HSP90AB1 LCOR LINC00624 LINC01554 NPSR1 OGT PRPF40A PSMC6 PSMD2 PTEN RPS3 SUMO2 SUMO4 VAV2 VRK2 YWHAG ZNRD2
Entrez ID		5708	10576
HPRD ID		05870	06895
Ensembl ID		ENSG00000175166	ENSG00000166226
Uniprot IDs		Q13200	P78371 V9HW96
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7UIH 7UJD 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N 9E8O 9E8Q	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasomal Protein Catabolic Process Proteasome Accessory Complex Proteasome Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome-activating Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Assembly Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Type II Interferon Regulation Of ERAD Pathway Presynaptic Cytosol	Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Positive Regulation Of Deoxyribonuclease Activity Protein-containing Complex Positive Regulation Of Protein Catabolic Process Kinase Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Translation Regulation Of Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Kinase Binding Positive Regulation Of Biosynthetic Process Response To Stress Response To Nutrient Levels Regulation Of Protein Localization To Cell Periphery Ubiquitin Protein Ligase Binding Mitophagy Tat Protein Binding Cellular Response To Nitrogen Starvation Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of TORC1 Signaling Regulation Of Nitric Oxide Metabolic Process TORC1 Signaling Proteasome Regulatory Particle, Base Subcomplex Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Catabolic Process Negative Regulation Of Translation Cellular Response To Starvation
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