PSMD2 and FKBP8

Number of citations of the paper that reports this interaction (PMID 19546213)
12

Data Source:
BioGRID (pull down)

		PSMD2	FKBP8
Gene Name		proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	FK506 binding protein 8, 38kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytosol Proteasome Regulatory Particle Membrane Proteasome Accessory Complex Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Enzyme Regulator Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Chaperone-mediated Protein Folding
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs		Bortezomib
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADRM1 BAG1 CALM1 CCT2 FAF2 FKBP8 LRIF1 NDRG1 NUB1 PSMC1 PSMC2 PSMD5 PTN TNFRSF1A UBE3C UBLCP1 UNC119 ZBTB16	15 interactors: ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL
Entrez ID		5708	23770
HPRD ID		05870	05327
Ensembl ID		ENSG00000175166	ENSG00000105701
Uniprot IDs		B4DX07 B4DXY1 E7EW34 E9PCS3 Q13200	J3KQ73 Q14318
PDB IDs			2AWG 2D9F 2F2D 2JWX 3EY6
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Amino Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Proteolysis Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Proteasome Assembly Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-protein Transferase Activity Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Intracellular Signal Transduction Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cellular Response To Oxygen Levels Regulation Of Cell Cycle Positive Regulation Of Myotube Differentiation Negative Regulation Of Autophagy Cellular Response To Stress Immune System Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Regulation Of Signaling G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Signaling Cellular Response To Stimulus Response To Stimulus Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Intracellular Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Myotube Differentiation Response To Stress Positive Regulation Of Striated Muscle Cell Differentiation Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Nucleocytoplasmic Transport Response To Inorganic Substance Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process
Tagcloud ?		actb applets arf1 bal bestkeeper bronchoalveolar canx ccl2 constantly ctt denominators equivalence g6pd gapdh genorm gnb2l1 gps1 housekeeping ifng irrespective normalisation normalization normalize normfinder psmb2 qrt rpl32 sarcoid sarcoidosis	e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization
Tagcloud (Difference) ?		actb applets arf1 bal bestkeeper bronchoalveolar canx ccl2 constantly ctt denominators equivalence g6pd gapdh genorm gnb2l1 gps1 housekeeping ifng irrespective normalisation normalization normalize normfinder psmb2 qrt rpl32 sarcoid sarcoidosis	e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization
Tagcloud (Intersection) ?