PARP11 and DTX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PARP11	DTX3
Description		poly(ADP-ribose) polymerase family member 11	deltex E3 ubiquitin ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body	Nucleoplasm Cytoplasm
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear Envelope Organization Spermatogenesis Protein Transport Cell Differentiation MRNA Transport Protein Auto-ADP-ribosylation	Notch Signaling Pathway Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Colorectal cancer ( 23263487) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Fasting insulin (dietary factor interaction) ( 24204828) Hematocrit ( 29403010) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Pancreas fat ( 34128465) Pulse pressure ( 27841878) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33272962) Total hippocampal volume ( 30279459) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		7 interacting genes: DTX3 GTPBP3 HOOK2 LHX3 LHX4 MDFI TRIP13	46 interacting genes: ARF5 BAG3 DTX1 DTX2 EPHB4 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19
Entrez ID		57097	196403
HPRD ID		15101	16842
Ensembl ID		ENSG00000111224	ENSG00000178498
Uniprot IDs		G3V0I3 Q9NR21	Q8N9I9
PDB IDs		2DK6
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Cell Differentiation In Spinal Cord Placenta Development Animal Organ Morphogenesis Prolactin Secreting Cell Differentiation TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Meiotic Recombination Checkpoint Signaling	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Protein Monoubiquitination Macromolecule Catabolic Process Protein K63-linked Ubiquitination ATP Binding ISG15 Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleotide Binding ISG15-protein Conjugation Nucleus Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Cell Surface Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Ephrin Receptor Signaling Pathway UBC13-MMS2 Complex Regulation Of Signal Transduction Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein K63-linked Ubiquitination Protein Binding Protein Catabolic Process
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