PARP11

Description		poly(ADP-ribose) polymerase family member 11
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Nuclear Envelope Organization Spermatogenesis Protein Transport Cell Differentiation MRNA Transport Protein Auto-ADP-ribosylation
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Colorectal cancer ( 23263487) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Fasting insulin (dietary factor interaction) ( 24204828) Hematocrit ( 29403010) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Pancreas fat ( 34128465) Pulse pressure ( 27841878) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33272962) Total hippocampal volume ( 30279459) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		7 interacting genes: DTX3 GTPBP3 HOOK2 LHX3 LHX4 MDFI TRIP13
Entrez ID		57097
HPRD ID		15101
Ensembl ID		ENSG00000111224
Uniprot IDs		G3V0I3 Q9NR21
PDB IDs		2DK6
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Cell Differentiation In Spinal Cord Placenta Development Animal Organ Morphogenesis Prolactin Secreting Cell Differentiation TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Meiotic Recombination Checkpoint Signaling
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