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PSMD3 and BLM
Number of citations of the paper that reports this interaction (PubMedID
15829507
)
0
Data Source:
BioGRID
(two hybrid)
PSMD3
BLM
Description
proteasome 26S subunit, non-ATPase 3
BLM RecQ like helicase
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
RecQ Family Helicase-topoisomerase III Complex
Protein-containing Complex
Molecular Function
Protein Binding
Enzyme Regulator Activity
Nucleotide Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
DNA Recombination
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA Recombination
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Resolution Of DNA Recombination Intermediates
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
T-circle Formation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Creatine kinase levels (
29403010
)
Lipoprotein (a) levels (
33730874
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Mitochondrial DNA copy number (
30704525
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
20172861
29066854
25096241
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
29403010
25096241
22037903
21738480
20139978
)
White blood cell count (basophil) (
27863252
)
White blood cell count (neutrophil) (
28158719
)
White blood cell types (
21738478
)
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
10 interacting genes:
BLM
CDC42
CEP44
ERBB2
NFKBIA
PRPF3
PTEN
SEM1
TMEM14B
ZBTB43
39 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF4
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TP53
TP53BP1
TRIM49
UBE2I
UPF2
USP37
WRN
Entrez ID
5709
641
HPRD ID
10170
05211
Ensembl ID
ENSG00000108344
ENSG00000197299
Uniprot IDs
O43242
B7ZKN7
H0YNU5
P54132
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
7XUW
7XV0
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Cycle Process
Identical Protein Binding
Dendritic Spine Morphogenesis
Embryonic Heart Tube Development
Regulation Of Mitotic Cell Cycle
Intracellular Signal Transduction
Cellular Component Assembly
Regulation Of Cell Cycle
Positive Regulation Of Epithelial Cell Proliferation
Neuron Projection Organization
Dendritic Spine Organization
Nervous System Development
Postsynapse Organization
Cellular Response To Epidermal Growth Factor Stimulus
Response To Epidermal Growth Factor
Nuclear Transport
Nucleocytoplasmic Transport
Heart Development
Negative Regulation Of Cell Differentiation
Negative Regulation Of Synaptic Vesicle Clustering
RNA Polymerase III General Transcription Initiation Factor Binding
Positive Regulation Of Transcription Initiation By RNA Polymerase II
8-hydroxy-2'-deoxyguanosine DNA Binding
Forked DNA-dependent Helicase Activity
Regulation Of Protein Phosphorylation
Telomeric G-quadruplex DNA Binding
DNA/DNA Annealing Activity
Positive Regulation Of RNA Biosynthetic Process
RecQ Family Helicase-topoisomerase III Complex
Regulation Of Phosphorylation
Protein-containing Complex
Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA-templated Transcription
Regulation Of Mitotic Cell Cycle Phase Transition
Telomeric D-loop Binding
Regulation Of Cell Cycle Phase Transition
Cellular Response To Camptothecin
Y-form DNA Binding
PML Body
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Population Proliferation
Neuron Projection Development
Apolipoprotein A-I Receptor Binding
Cellular Localization
Endothelin Receptor Signaling Pathway Involved In Heart Process
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Neuropilin Signaling Pathway
System Development
GBD Domain Binding
DNA Damage Response
DNA Repair
DNA Metabolic Process
Chromosome Organization
Cellular Response To Stress
Double-strand Break Repair
Macromolecule Metabolic Process
Chromosome, Telomeric Region
PML Body
Nucleic Acid Metabolic Process
Nucleoplasm
Response To Stress
Telomere Maintenance
Regulation Of DNA Metabolic Process
DNA Recombination
Telomere Organization
Regulation Of Cell Cycle
Chromosome
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA Metabolic Process
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Replication Fork
Signal Transduction In Response To DNA Damage
Response To Radiation
Regulation Of DNA Replication
Interstrand Cross-link Repair
Nuclear Body
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Damage Checkpoint Signaling
Organelle Organization
Nuclear Chromosome
T-circle Formation
Cellular Response To Ionizing Radiation
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Replicative Senescence
Regulation Of DNA Recombination
Recombinational Repair
Replication Fork Processing
DNA Replication
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of Chromosome Organization
Condensed Nuclear Chromosome
Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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