COQ9 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COQ9	ORMDL1
Description		coenzyme Q9	ORMDL sphingolipid biosynthesis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Lipid Binding Isoprenoid Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Ubiquinone Biosynthetic Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways		Ubiquinol biosynthesis	Sphingolipid de novo biosynthesis
Drugs
Diseases		Coenzyme Q10 deficiency
GWAS			Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		33 interacting genes: ACSF2 ACTL6B ADIPOQ ALDH18A1 ANO8 BMP10 CCL4L2 CLNK COQ4 COQ8A CTSA CTXN3 CYB561D2 CYBC1 EHHADH GALNT2 HMOX1 KIR2DL3 MGLL ORMDL1 PLSCR2 SCARF1 SLC13A1 STX3 TEX264 TMEM14C TMEM79 TMEM86A TNFRSF10C TRAF3IP3 TSPAN33 VSTM1 WFDC2	42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		57017	94101
HPRD ID		13157	15092
Ensembl ID		ENSG00000088682	ENSG00000128699
Uniprot IDs		O75208	Q9P0S3
PDB IDs		4RHP 6AWL 6DEW 7SSP 7SSS
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane
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