PAK6 and DLL4

		PAK6	DLL4
Description		p21 (RAC1) activated kinase 6	delta like canonical Notch ligand 4
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity	Notch Binding Calcium Ion Binding Protein Binding Receptor Ligand Activity
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Blood Vessel Remodeling Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Cell Communication Signal Transduction Notch Signaling Pathway Nervous System Development Visual Perception Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation T Cell Differentiation Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Animal Organ Development System Development Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		19 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 TPD52L1	2 interacting genes: NOTCH1 NOTCH4
Entrez ID		56924	54567
HPRD ID		06426	05540
Ensembl ID		ENSG00000137843	ENSG00000128917
Uniprot IDs		Q9NQU5	Q9NR61
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	5MVX
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway	Luteolysis Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Cell Adhesion Molecule Production Regulation Of Cell Adhesion Molecule Production Notch Binding Positive Regulation Of Smooth Muscle Cell Differentiation Endothelial Cell Differentiation Regulation Of Endothelial Cell Differentiation Ovulation Cycle Process Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Epithelial To Mesenchymal Transition Mesenchymal Cell Differentiation Notch Signaling Pathway Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Branching Morphogenesis Of An Epithelial Tube Developmental Growth Involved In Morphogenesis Regulation Of Muscle Cell Differentiation Regulation Of Epithelial Cell Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Notch Signaling Involved In Heart Development Endocardium Morphogenesis Mitral Valve Formation Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Negative Regulation Of Cell-cell Adhesion Auditory Receptor Cell Fate Commitment Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Anatomical Structure Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation
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