MEIS3 and PIP4K2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MEIS3	PIP4K2A
Description		Meis homeobox 3	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Lysosome Autophagosome Cytosol Plasma Membrane Membrane Cell Projection
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity
	Biological Process	Angiogenesis Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Positive Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process Regulation Of Autophagy Megakaryocyte Development Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion Vesicle-mediated Cholesterol Transport 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways			Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Height ( 31562340) Lymphocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		22 interacting genes: ATXN1L CCDC116 ENKD1 FAM110A FAM110B FAM161B FAM90A1 HGS HOXA13 INTS4 LENG1 LMO3 MBD3 PIP4K2A PRPF31 PSORS1C2 SUOX TCL1B TLE5 TSGA10IP VEZF1 ZNF417	6 interacting genes: BTK GSTK1 MEIS3 RAC1 RPS6KB1 TEC
Entrez ID		56917	5305
HPRD ID		14386	11931
Ensembl ID		ENSG00000105419	ENSG00000150867
Uniprot IDs		H0YNA8 H3BLU4 Q49A38 Q99687	P48426
PDB IDs			2YBX 6OSP 6UX9 6YM3 6YM4 6YM5 7N6Z 7N71 7N7J 7N7K 7N7L 7N7M 7N7N 7N7O 8C8C
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Type I Hypersensitivity Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Protein Phosphorylation B Cell Receptor Signaling Pathway T Cell Receptor Signaling Pathway Developmental Process Phosphorylation Protein Kinase Activity B Cell Affinity Maturation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Protein Tyrosine Kinase Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Synoviocyte Proliferation Antigen Receptor-mediated Signaling Pathway Cellular Response To Molecule Of Fungal Origin Kinase Activity Negative Regulation Of TORC2 Signaling Histamine Secretion By Mast Cell Response To Molecule Of Fungal Origin Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Cellular Developmental Process Transferase Activity Intracellular Signal Transduction Histamine Secretion Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of CGAS/STING Signaling Pathway Nucleotide Binding Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Homeostasis Of Number Of Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell
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