C1GALT1C1 and B3GNT2

Number of citations of the paper that reports this interaction (PMID 12464682)
82

Data Source:
HPRD (in vitro)

		C1GALT1C1	B3GNT2
Gene Name		C1GALT1-specific chaperone 1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Golgi Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding	Galactosyltransferase Activity N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Platelet Activation Platelet Morphogenesis Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity	Carbohydrate Metabolic Process Protein O-linked Glycosylation Axon Guidance Sensory Perception Of Smell Biological_process Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Poly-N-acetyllactosamine Biosynthetic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Post-translational protein modification O-linked glycosylation of mucins O-linked glycosylation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism O-linked glycosylation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Post-translational protein modification Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome O-linked glycosylation of mucins MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 20062062) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		3 interactors: B3GNT2 C1GALT1 LGALS3	2 interactors: C1GALT1C1 TMEM246
Entrez ID		29071	10678
HPRD ID		06462	09279
Ensembl ID		ENSG00000171155	ENSG00000170340
Uniprot IDs		Q96EU7	Q9NY97
PDB IDs
Enriched GO Terms of Interacting Partners?		O-glycan Processing Protein O-linked Glycosylation Negative Regulation Of Immunological Synapse Formation Post-translational Protein Modification Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Mononuclear Cell Migration Mononuclear Cell Migration Macromolecule Glycosylation Protein Glycosylation Poly-N-acetyllactosamine Biosynthetic Process Glycosylation Poly-N-acetyllactosamine Metabolic Process Glycoprotein Biosynthetic Process Eosinophil Chemotaxis Glycoprotein Metabolic Process Eosinophil Migration Epithelial Cell Differentiation Positive Regulation Of Calcium Ion Import Monocyte Chemotaxis Intestinal Epithelial Cell Development Chemotaxis Macrophage Chemotaxis Intestinal Epithelial Cell Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Calcium Ion Import Keratan Sulfate Biosynthetic Process Cell Differentiation Keratan Sulfate Metabolic Process Positive Chemotaxis Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process System Development Carbohydrate Metabolic Process Columnar/cuboidal Epithelial Cell Development Regulation Of T Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Endocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelium Development Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Regulation Of Lymphocyte Apoptotic Process Locomotion Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Ion Transmembrane Transport Polysaccharide Metabolic Process Positive Regulation Of Leukocyte Migration Movement Of Cell Or Subcellular Component	Platelet Morphogenesis
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