CES1 and GUSB

Number of citations of the paper that reports this interaction (PubMedID 10562416)
0

Data Source:
HPRD (in vitro, in vivo)

		CES1	GUSB
Description		carboxylesterase 1	glucuronidase beta
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol	Extracellular Region Extracellular Space Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Sterol Ester Esterase Activity Protein Binding Hydrolase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Carboxylesterase Activity	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucuronidase Activity Signaling Receptor Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Domain Specific Binding Carbohydrate Binding
	Biological Process	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process
Pathways		Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds Physiological factors Aspirin ADME	CS/DS degradation Hyaluronan degradation MPS VII - Sly syndrome (Hyaluronan metabolism) Neutrophil degranulation MPS VII - Sly syndrome (CS/DS degradation)
Drugs		Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases			Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS		Response to dabigatran etexilate treatment ( 23467860)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX	3 interacting genes: CES1 GIT2 PRKACA
Entrez ID		1066	2990
HPRD ID		00268	02018
Ensembl ID		ENSG00000198848	ENSG00000169919
Uniprot IDs		P23141	P08236
PDB IDs		1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H 8EOR 9KWL 9KWM	1BHG 3HN3
Enriched GO Terms of Interacting Partners?			Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Small Molecule Metabolic Process Regulation Of Lipid Biosynthetic Process Methylumbelliferyl-acetate Deacetylase Activity Regulation Of Bile Acid Secretion Carboxylesterase Activity Sterol Ester Esterase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process CAMP-dependent Protein Kinase Activity Regulation Of Bile Acid Biosynthetic Process Regulation Of Bile Acid Metabolic Process Medium-chain Fatty Acid Metabolic Process Negative Regulation Of Cholesterol Storage CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Cellular Response To Sterol Negative Regulation Of Lipid Storage Regulation Of Secretion Reverse Cholesterol Transport Cellular Response To Cholesterol Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Response To Laminar Fluid Shear Stress Sperm Capacitation Cellular Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis
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