ERO1B and GNG4

		ERO1B	GNG4
Description		endoplasmic reticulum oxidoreductase 1 beta	G protein subunit gamma 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Oxidoreductase Activity Thiol Oxidase Activity Unfolded Protein Binding FAD Binding	Protein Binding G-protein Beta-subunit Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Insulin Processing Extracellular Matrix Organization Protein Folding In Endoplasmic Reticulum Glucose Homeostasis Cell Redox Homeostasis Protein Maturation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Growth
Pathways		Insulin processing	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases
GWAS			Aging traits ( 17903295) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Type 2 diabetes ( 30297969)
Interacting Genes		4 interacting genes: BRCA1 ERP44 OGT P4HB	9 interacting genes: FHL2 GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1
Entrez ID		56605	2786
HPRD ID		13279	11978
Ensembl ID		ENSG00000086619	ENSG00000168243
Uniprot IDs		Q86YB8	B1APZ0 P50150
PDB IDs
Enriched GO Terms of Interacting Partners?			Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Atrial Cardiac Muscle Cell Development Protein-containing Complex Binding Lysosomal Membrane Death-inducing Signaling Complex Assembly GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Spliceosomal Complex Disassembly Synapse Light Adaption U2-type Post-mRNA Release Spliceosomal Complex
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