KLK7 and CDSN

Number of citations of the paper that reports this interaction (PMID 15140227)
59

Data Source:
BioGRID (enzymatic study)

		KLK7	CDSN
Gene Name		kallikrein-related peptidase 7	corneodesmosin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Epidermal Lamellar Body	Cornified Envelope Cell-cell Junction Desmosome Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Protein Homodimerization Activity
	Biological Process	Proteolysis Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization	Cell Adhesion Epidermis Development Single Organismal Cell-cell Adhesion Keratinocyte Differentiation Skin Morphogenesis
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Hematology traits ( 23263863) HIV-1 control ( 20041166) White blood cell count ( 20139978 21738480)
Protein-Protein Interactions		2 interactors: APP CDSN	5 interactors: CEP55 KLK7 UBQLN4 UCHL5 ZDHHC17
Entrez ID		5650	1041
HPRD ID		05115	03998
Ensembl ID		ENSG00000169035	ENSG00000204539
Uniprot IDs		B4DHX9 P49862	Q15517
PDB IDs		2QXG 2QXH 2QXI 2QXJ 3BSQ
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Skin Morphogenesis Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Keratinocyte Differentiation Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior
Tagcloud ?		chymotrypsin corneodesmosomes corneum desmocollin desmoglein detached dsc1 dsg1 filaggrin gels kallikreins kazal klk5 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte spink5 stratum therapeutically thicker transfecting	ageing alleviates collagen corneodesmosin corneodesmosomal desmocollin desmoglein desmosomes desquamation diphosphate dsc1 dsg1 equivalents fdp fibres fluxes fructose glycolytic kallikrein keratinocytes klk klk7 metabolite nheks peeling proteases serca2 ses ultraviolet
Tagcloud (Difference) ?		chymotrypsin corneodesmosomes corneum detached filaggrin gels kallikreins kazal klk5 knockdowns lekti lympho netherton omim organotypic parakeratotic populated recapitulates scce scte spink5 stratum therapeutically thicker transfecting	ageing alleviates collagen corneodesmosin corneodesmosomal desmosomes desquamation diphosphate equivalents fdp fibres fluxes fructose glycolytic kallikrein keratinocytes klk metabolite nheks peeling proteases serca2 ses ultraviolet
Tagcloud (Intersection) ?		desmocollin desmoglein dsc1 dsg1 klk7