TRPV5 and ANXA2

Number of citations of the paper that reports this interaction (PMID 12660155)
48

Data Source:
BioGRID (pull down)

		TRPV5	ANXA2
Gene Name		transient receptor potential cation channel, subfamily V, member 5	annexin A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Calcium Ion Transport Ion Transmembrane Transport Protein Tetramerization Transmembrane Transport Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Dissolution of Fibrin Clot Orphan transporters
Drugs			Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ANXA2 CALB1 EWSR1 S100A10	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		56302	302
HPRD ID		05981	01061
Ensembl ID		ENSG00000127412	ENSG00000182718
Uniprot IDs		Q9NQA5	P07355
PDB IDs			1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Membrane Raft Assembly Protein Heterotetramerization Membrane Raft Organization Membrane Assembly Membrane Biogenesis Establishment Of Protein Localization To Plasma Membrane Membrane Budding Protein Tetramerization Positive Regulation Of Binding Metanephric Connecting Tubule Development Protein Heterooligomerization Protein Localization To Plasma Membrane Vesicle Organization Plasma Membrane Organization Establishment Of Protein Localization To Membrane Metanephric Part Of Ureteric Bud Development Regulation Of Binding Metanephric Distal Convoluted Tubule Development Metanephric Distal Tubule Development Protein Localization To Membrane Osteoclast Development Metanephric Collecting Duct Development Positive Regulation Of Organelle Organization Endomembrane System Organization Distal Tubule Development Protein Oligomerization Collecting Duct Development Short-term Memory Metanephric Nephron Tubule Development Fibrinolysis Positive Regulation Of Vesicle Fusion Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Retina Layer Formation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Targeting To Plasma Membrane Metanephric Epithelium Development Metanephros Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Vesicle Fusion Negative Regulation Of Blood Coagulation Membrane Organization Positive Regulation Of Stress Fiber Assembly Long-term Memory Osteoclast Differentiation Negative Regulation Of Coagulation Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Collagen Fibril Organization Regulation Of Organelle Organization	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?		ca2 casr clin collecting excretion extends furosemide handling hypoparathyroidism imcd invest loupy lowers mathematical medullary microperfusion mtal nephron pumps raised reabsorption reproduces romk sensing sigmoidal stone transepithelial tubules vanilloid	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?		ca2 casr clin collecting excretion extends furosemide handling hypoparathyroidism imcd invest loupy lowers mathematical medullary microperfusion mtal nephron pumps raised reabsorption reproduces romk sensing sigmoidal stone transepithelial tubules vanilloid	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?