SEPTIN3 and CKS1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEPTIN3	CKS1B
Description		septin 3	CDC28 protein kinase regulatory subunit 1B
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Septin Ring Microtubule Cytoskeleton Septin Complex Cell Division Site Synapse Presynapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Intracellular Protein Localization Cell Division Cytoskeleton-dependent Cytokinesis	Regulation Of Mitotic Cell Cycle Cell Division
Pathways			SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs			Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS			Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)
Interacting Genes		23 interacting genes: CDC37 CHRM3 CKS1B CREBBP DDIT4L EIF6 GABARAPL2 LASP1 MAP1LC3B MAPK6 MOB1A NTAQ1 PELI2 PRKG1 RNF4 RNF8 RSPH1 SDCBP SELENOF SEPTIN1 SLC39A14 SNCA WBP2	57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9
Entrez ID		55964	1163
HPRD ID		10515	00299
Ensembl ID		ENSG00000100167	ENSG00000173207
Uniprot IDs		A0A2R8Y4H2 Q9UH03	P61024 Q5T178
PDB IDs		3SOP 4Z51 4Z54 6UQQ	1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Mitophagy Cellular Response To Nitrogen Starvation Regulation Of Phosphorus Metabolic Process Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Meiotic Spindle Ubiquitin-ubiquitin Ligase Activity Protein Modification Process Regulation Of Glutamate Secretion Sperm DNA Condensation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Protein K48-linked Ubiquitination Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Secretion By Cell Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Ketone Metabolic Process Protein K6-linked Ubiquitination Protein Polyubiquitination Interleukin-5 Receptor Complex Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Catabolic Process Phospholipid Binding Ubiquitin Protein Ligase Binding FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Monoatomic Anion:monoatomic Cation Symporter Activity Protein-N-terminal Glutamine Amidohydrolase Activity	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity
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