MESP1 and ZIC3

Number of citations of the paper that reports this interaction (PubMedID 36413948)
0

Data Source:
BioGRID (two hybrid)

		MESP1	ZIC3
Description		mesoderm posterior bHLH transcription factor 1	Zic family zinc finger 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Heart Looping Heart Morphogenesis Heart Induction Secondary Heart Field Specification Embryonic Heart Tube Morphogenesis Cardiac Atrium Formation Cardiac Ventricle Formation Sinus Venosus Morphogenesis Growth Involved In Heart Morphogenesis Cardioblast Anterior-lateral Migration Cardioblast Migration Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Gastrulation Mesodermal Cell Migration Gene Expression Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Negative Regulation Of Mesodermal Cell Fate Specification Negative Regulation Of Endodermal Cell Fate Specification Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lateral Mesoderm Development Positive Regulation Of Striated Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cardiac Cell Fate Determination Sinoatrial Node Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Cardioblast Migration To The Midline Involved In Heart Field Formation Positive Regulation Of Hepatocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	Skeletal System Development Neural Plate Development Heart Looping Atrial Cardiac Muscle Tissue Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Gastrulation Pattern Specification Process Nervous System Development Central Nervous System Development Mesoderm Development Heart Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Gene Expression Stem Cell Population Maintenance Hippocampus Development Olfactory Bulb Development Cell Differentiation Neuron Differentiation Lung Development Germ-line Stem Cell Population Maintenance Forebrain Development Limb Morphogenesis Central Nervous System Segmentation Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Outer Ear Morphogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Paraxial Mesoderm Development Stem Cell Differentiation Face Development Left/right Pattern Formation Left/right Axis Specification Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Primitive Streak Formation Maintenance Of Cell Number Cranial Skeletal System Development
Pathways		Cardiogenesis	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Refractive error ( 32231278)
Interacting Genes		1 interacting genes: ZIC3	7 interacting genes: CTNNB1 GLI3 MESP1 SRF TP53 TWIST1 UBASH3A
Entrez ID		55897	7547
HPRD ID		10070	02225
Ensembl ID		ENSG00000166823	ENSG00000156925
Uniprot IDs		Q9BRJ9	O60481
PDB IDs			2EJ4 2RPC
Enriched GO Terms of Interacting Partners?		Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Axial Mesoderm Development Germ-line Stem Cell Population Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Liver Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Paraxial Mesoderm Development Outer Ear Morphogenesis Primitive Streak Formation Left/right Axis Specification Atrial Cardiac Muscle Tissue Development Left/right Pattern Formation Cranial Skeletal System Development Face Development Olfactory Bulb Development Cardiac Muscle Tissue Development MRNA Transcription MRNA Transcription By RNA Polymerase II Gastrulation Mesenchyme Development Segmentation Embryonic Pattern Specification Mesoderm Development Heart Looping Forebrain Development Hippocampus Development Embryonic Heart Tube Morphogenesis Axis Specification Smoothened Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Limb Morphogenesis Epithelial Tube Morphogenesis Lung Development Stem Cell Differentiation Stem Cell Population Maintenance Maintenance Of Cell Number Striated Muscle Tissue Development Central Nervous System Development Muscle Tissue Development Anterior/posterior Pattern Specification Skeletal System Development Epithelium Development Heart Development Regionalization Gene Expression Transcription Coactivator Activity Transcription By RNA Polymerase II	Heart Development Gastrulation Pattern Specification Process Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regionalization In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Cis-regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Smooth Muscle Cell Differentiation Histone Deacetylase Binding Developmental Growth Animal Organ Development Tissue Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Cardiac Vascular Smooth Muscle Cell Differentiation Neuroblast Proliferation Embryonic Digit Morphogenesis Animal Organ Morphogenesis Formation Of Primary Germ Layer Cell Motility Forebrain Development Positive Regulation Of DNA-templated Transcription Initiation Cranial Suture Morphogenesis Regulation Of MiRNA Transcription Stem Cell Proliferation Embryonic Skeletal System Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Initiation Vascular Associated Smooth Muscle Cell Differentiation Tube Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Thymocyte Apoptotic Process Neural Precursor Cell Proliferation Tissue Development Hematopoietic Or Lymphoid Organ Development Morphogenesis Of An Epithelium
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