TBC1D23 and EIF3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D23	EIF3B
Description		TBC1 domain family member 23	eukaryotic translation initiation factor 3 subunit B
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GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle WASH Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	Nervous System Development Brain Development Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Animal Organ Development Vesicle Tethering To Golgi Embryonic Brain Development	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Axial length ( 24144296) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		14 interacting genes: ATOSB CAGE1 EHD2 EIF3B FOXP1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOPCHAP1 SSBP3 STK11 TIAM1 WDR62	18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1
Entrez ID		55773	8662
HPRD ID		07727	06795
Ensembl ID		ENSG00000036054	ENSG00000106263
Uniprot IDs		Q9NUY8	P55884
PDB IDs		6JL7 6JM5 8JJ9 8QQF	2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Growth Negative Regulation Of Organ Growth Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Neurogenesis Negative Regulation Of Growth Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Box C/D Methylation Guide SnoRNP Complex Binding Positive Regulation Of Nervous System Development Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Anterior Head Development Positive Regulation Of Interleukin-21 Production	Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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