OSGEP and GP1BA

Number of citations of the paper that reports this interaction (PubMedID 9092683)
0

Data Source:
HPRD (in vitro)

		OSGEP	GP1BA
Description		O-sialoglycoprotein endopeptidase	glycoprotein Ib platelet subunit alpha
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GO Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metal Ion Binding TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity
	Biological Process	TRNA Threonylcarbamoyladenosine Modification TRNA Modification TRNA Processing	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway
Pathways		tRNA modification in the nucleus and cytosol	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs			Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases			Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Food addiction ( 27106561)	Blood protein levels ( 30072576) Keratoconus ( 33649486) Mean platelet volume ( 27863252 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		25 interacting genes: CIAPIN1 CRIP2 EMCN GP1BA HPS6 LAGE3 LENG1 LGALS4 MUC1 NR3C1 NVL OPTC PDE4DIP PKP4 RBM48 REX1BD SF3B3 SHC1 SP110 SPRED1 TNS1 WDR82 WIZ ZNF579 ZNF775	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		55644	2811
HPRD ID		10133	01976
Ensembl ID		ENSG00000092094	ENSG00000185245
Uniprot IDs		Q9NPF4	L7UYB8 P07359
PDB IDs		6GWJ	1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS
Enriched GO Terms of Interacting Partners?			Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process
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