KIF27 and TLE1

		KIF27	TLE1
Description		kinesin family member 27	TLE family member 1, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Kinesin Complex Microtubule Cilium Cell Projection	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Ventricular System Development Cell Projection Organization Establishment Of Localization In Cell Cilium Assembly	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Multiple sclerosis ( 31604244) Reaction time ( 29844566) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 32499647 30718926 30297969 30054458 28869590 26818947 24509480) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		3 interacting genes: FOXP1 MAGEA3 MAGEA6	83 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TSC22D1 UTY ZFP64
Entrez ID		55582	7088
HPRD ID		11179	02557
Ensembl ID		ENSG00000165115	ENSG00000196781
Uniprot IDs		Q86VH2	B4DEF9 Q04724 Q59EF7
PDB IDs			1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Autophagy Histone Deacetylase Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-21 Production Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of RNA Metabolic Process Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Signaling Monocyte Activation Endothelial Cell Activation T Follicular Helper Cell Differentiation Caspase Binding Regulation Of Autophagy Negative Regulation Of Catabolic Process Beta-catenin-TCF Complex Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of B Cell Apoptotic Process Striatum Development Regulation Of Defense Response To Bacterium Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation Core Promoter Sequence-specific DNA Binding Negative Regulation Of Anoikis Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Intracellular Signal Transduction	Sequence-specific Double-stranded DNA Binding Chromatin Developmental Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regionalization Negative Regulation Of DNA-templated Transcription Cellular Developmental Process Negative Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Mesenchymal Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Transcription Corepressor Binding
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