CAMK2N1 and GRIN2B

Number of citations of the paper that reports this interaction (PMID 12650977)
5

Data Source:
HPRD (in vivo)

		CAMK2N1	GRIN2B
Gene Name		calcium/calmodulin-dependent protein kinase II inhibitor 1	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways			EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine
Diseases
GWAS			Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)
Protein-Protein Interactions		1 interactors: GRIN2B	40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		55450	2904
HPRD ID		13112	00697
Ensembl ID		ENSG00000162545
Uniprot IDs		Q7Z7J9	Q13224
PDB IDs			1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase A Signaling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Behavioral Response To Pain Suckling Behavior Startle Response Behavioral Fear Response Detection Of Mechanical Stimulus Involved In Sensory Perception Response To Pain Fear Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Detection Of Mechanical Stimulus Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Multicellular Organismal Response To Stress Sensory Perception Of Pain Ephrin Receptor Signaling Pathway Feeding Behavior Membrane Depolarization Memory Neuromuscular Process Learning Response To Ethanol Regulation Of Synaptic Plasticity Detection Of Abiotic Stimulus Sensory Perception Of Mechanical Stimulus Calcium Ion Transmembrane Transport Response To Mechanical Stimulus Learning Or Memory Regulation Of Membrane Potential Cognition Regulation Of Synaptic Transmission Calcium Ion Transport Axon Guidance Detection Of Stimulus Involved In Sensory Perception Single-organism Behavior	Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation
Tagcloud ?		accompanied arrested biomarker calmodulin camkii castration cloned comparing conversely correlates erbb2 erk g0 g1 incurable mek opposite phases phenotypes pi3k plays predicts prostate re serve suppressive therapies tumorigenesis vegf	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		accompanied arrested biomarker calmodulin camkii castration cloned comparing conversely correlates erbb2 erk g0 g1 incurable mek opposite phases phenotypes pi3k plays predicts prostate re serve suppressive therapies tumorigenesis vegf	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?