WDR33 and SH3GL3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WDR33	SH3GL3
Description		WD repeat domain 33	SH3 domain containing GRB2 like 3, endophilin A3
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GO Annotations	Cellular Component	Fibrillar Center Collagen Trimer Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	Acrosomal Vesicle Cytoplasm Endosome Early Endosome Membrane Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Postreplication Repair MRNA Processing Spermatogenesis MRNA 3'-end Processing	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) White blood cell count ( 32888494)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 18391951 28552196 25282103 20397748 18391950) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		19 interacting genes: CDK4 EEF1G GIT1 KAT7 MIR19A MIR19B1 MIR34B MIR92A2 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UBC UTP14A WWOX ZBTB16 ZHX1	52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		55339	6457
HPRD ID		11680	04528
Ensembl ID		ENSG00000136709	ENSG00000140600
Uniprot IDs		Q9C0J8	Q99963
PDB IDs		6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Regulation Of Extracellular Matrix Assembly Response To Actinomycin D Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Post-transcriptional Gene Silencing Negative Regulation Of Matrix Metallopeptidase Secretion Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Differentiation Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Regulation Of Heart Growth Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Bacterial Lipopeptide Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell Growth Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Regulation Of Cell Cycle Regulation Of Stem Cell Proliferation RISC Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Organ Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression MRNA Destabilization Regulation Of Cell Differentiation RNA Destabilization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial To Mesenchymal Transition	Presynapse Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Presynaptic Cytosol Central Nervous System Development Cytoplasmic Side Of Mitochondrial Outer Membrane Cytoplasm Negative Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Vocal Learning Observational Learning Synapse
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