SMG8 and SMG1

Number of citations of the paper that reports this interaction (PubMedID 19417104)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		SMG8	SMG1
Description		SMG8 nonsense mediated mRNA decay factor	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Chromatoid Body
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Protein Kinase Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus DNA Damage Response Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: RNF10 SMG1	10 interacting genes: CDH5 PRKCI RNF10 SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		55181	23049
HPRD ID		08551	06123
Ensembl ID		ENSG00000167447	ENSG00000157106
Uniprot IDs		Q8ND04	Q96Q15
PDB IDs		6L54 6SYT 6Z3R 7PW4 7PW5 7PW8	6L53 6L54 6SYT 6Z3R 7PW4 7PW5 7PW6 7PW7 7PW8 7PW9
Enriched GO Terms of Interacting Partners?			Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Macromolecule Catabolic Process MRNA Transport RNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleobase-containing Compound Transport MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Catabolic Process Nuclear Export Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Glial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of RNA Splicing Nuclear Transport Nucleocytoplasmic Transport Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Late Endosome To Lysosome Transport Nucleic Acid Metabolic Process Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Biosynthetic Process Cellular Localization Intracellular Monoatomic Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Regulation Of Gliogenesis Double-stranded DNA Helicase Activity Supraspliceosomal Complex VCB Complex Regulation Of Telomere Maintenance Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Golgi Vesicle Budding
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