SMG8 and SMG1

Number of citations of the paper that reports this interaction (PMID 19417104)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		SMG8	SMG1
Gene Name		SMG8 nonsense mediated mRNA decay factor	SMG1 phosphatidylinositol 3-kinase-related kinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Gene Expression Regulation Of Protein Kinase Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Response To Stress Gene Expression Peptidyl-serine Phosphorylation Protein Autophosphorylation Phosphatidylinositol Phosphorylation
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SMG1	8 interactors: CDH5 PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A
Entrez ID		55181	23049
HPRD ID		08551	06123
Ensembl ID		ENSG00000167447	ENSG00000157106
Uniprot IDs		Q8ND04	Q96Q15
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Export From Nucleus RNA Export From Nucleus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Phosphatidylinositol Phosphorylation Lipid Phosphorylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Peptidyl-serine Phosphorylation Nuclear Export MRNA Transport RNA Transport Nuclear-transcribed MRNA Catabolic Process Double-strand Break Repair RNA Localization MRNA Catabolic Process RNA Catabolic Process Lipid Modification Protein Autophosphorylation Phosphatidylinositol Metabolic Process DNA Recombination Nucleocytoplasmic Transport Nuclear Transport Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Transport RNA Transport RNA Localization Aromatic Compound Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Catabolic Process Nuclear Export Cytoplasmic Transport Intracellular Transport Catabolic Process RNA Metabolic Process Establishment Of Localization In Cell Gene Expression Cellular Localization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Junction Assembly Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Histone MRNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Monopolar Cell Polarity Blood Vessel Maturation Regulation Of Translation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Translational Termination Dosage Compensation Golgi Vesicle Budding Positive Regulation Of Glial Cell Proliferation Anatomical Structure Regression Histone MRNA Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Posttranscriptional Regulation Of Gene Expression
Tagcloud ?			acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Difference) ?			acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Intersection) ?