EPHA8 and PIK3CG

Number of citations of the paper that reports this interaction (PubMedID 11416136)
43

Data Source:
HPRD (in vitro, in vivo)

		EPHA8	PIK3CG
Description		EPH receptor A8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Identical Protein Binding Ephrin Receptor Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Protein Serine Kinase Activity
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus	Angiogenesis Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Endothelial Cell Migration T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Cell Migration Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Cellular Response To CAMP Neutrophil Extravasation Hepatocyte Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Fibroblast Apoptotic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS
Drugs		Fostamatinib	Staurosporine Myricetin LY-294002 Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE Wortmannin 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Duvelisib Fostamatinib
Diseases
GWAS		Serum alkaline phosphatase levels ( 33547301)	Antisaccade task score ( 31596458) Blood pressure ( 21909110) Carotid intima media thickness ( 21909108 30510157) Carotid plaque ( 30510157) Mean platelet volume ( 22423221 19820697 22139419 28031487 24026423) Metabolite levels ( 23823483) Platelet aggregation ( 29185836) Platelet count ( 22139419 22423221 29066854 29403010) Pulse pressure ( 29403010 30487518 26390057 28739976 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	22 interacting genes: CD28 EPHA8 GAB1 GRB2 GRK2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PIK3R6 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		2046	5294
HPRD ID		01493	03135
Ensembl ID		ENSG00000070886	ENSG00000105851
Uniprot IDs		P29322	A8K9G9 P48736
PDB IDs		1UCV 1X5L 3KUL	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4HVB 4J6I 4KZ0 4KZC 4PS3 4PS7 4PS8 4URK 4WWN 4WWO 4WWP 4XX5 4XZ4 5EDS 5G2N 5G55 5JHA 5JHB 5KAE 5OQ4 5T23 6AUD 6C1S 6FH5 6GQ7 6T3B 6T3C 6XRL 6XRM 6XRN 7JWE 7JWZ 7JX0 7KKE 7MEZ 7Z61 8DP0 8SC8 9GG9
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation	T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol 3-kinase Complex Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphatidylinositol 3-kinase Complex, Class IA Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Regulation Of Cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Activation Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Glial Cell Development Positive Regulation Of Gliogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Mechanical Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Programmed Cell Death Immune System Process Plasma Membrane Cell Development Immune Response Regulation Of Gliogenesis Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Regulated Exocytosis
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