EPHA8 and DARS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EPHA8	DARS2
Description		EPH receptor A8	aspartyl-tRNA synthetase 2, mitochondrial
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding	TRNA Binding Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Mitochondrial tRNA aminoacylation
Drugs		Fostamatinib	Aspartic acid
Diseases			Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Serum alkaline phosphatase levels ( 33547301)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	16 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT CFTR COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50
Entrez ID		2046	55157
HPRD ID		01493	07677
Ensembl ID		ENSG00000070886	ENSG00000117593
Uniprot IDs		P29322	A0A3B3IT01 A0A3B3ITS3 Q6PI48 Q9H9J7
PDB IDs		1UCV 1X5L 3KUL	4AH6
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation	Aminoacyl-tRNA Synthetase Multienzyme Complex
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